Clonal hematopoiesis (CH) is the age-related expansion of mutated blood stem cell clones that increases the risk of blood cancer. A recent publication shows that #IL1RAP isn’t just a marker of CH, it appears to drive it.

lnkd.in/eaCzJUwM

#ClonalHematopoiesis #AML #DrugTarget #CancerPrevention

Elevated clonal hematopoiesis in 9/11 first responders has distinct age-related patterns and relies on IL1RAP for clonal expansion - PubMed Environmental exposures are linked to precancerous hematologic conditions, but studies in cohorts with well-defined exposures are limited. We sequenced blood samples from a large cohort of first-respo...

#IL1RAP in clonal heamatopoiesis #AML pubmed.ncbi.nlm.nih.gov/41031953/

Plus the loss of #IL1RAP is profoundly impacting LSC colony-forming ability, paving further the way for novel approaches for the treatment of r/r AML

Targeting IL-1/IRAK1/4 signaling in Acute Myeloid Leukemia Stem Cells Following Treatment and Relapse Therapies for acute myeloid leukemia (AML) face formidable challenges due to relapse, often driven by leukemia stem cells (LSCs). Strategies targeting LSCs hold promise for enhancing outcomes, yet pai...

From the group that previously unveiled large-scale changes in the phenotype and genetic profile of AML LSCs, they are now demonstrating that #IL1RAP is consistently maintained during disease progression.-> 🎯 #CCTx001 🎯 #ADV101
www.biorxiv.org/content/10.1...
#AML #ADC #CellTherapy

Our recent poster on the therapeutic potential of ADV-101, a first in class #ADC targeting #IL1RAP in esophageal cancer is now on our website 🔬👩‍🔬

advesya.com/adv-101-prec...

Paper: IL-1RAP Is a Targetable Surface Antigen in Relapsed/Refractoy AML

#IL1RAP is demonstrating important characteristics as an optimal Target for the treatment of #AML. See this Abstract from our collaborators at ALFA that will be presented at the upcoming #AHS24 conference ash.confex.com/ash/2024/web...