In Situ Construction of Imidazopyridinium Fluorescent Labels for Bioconjugation Chromophore engineering of isoquinoline aldehydes generates TICT-based fluorogenic dyes for in situ labeling of diverse (bio)molecules with large Stokes shifts compatible with cell imaging.

🚀 Just published! In PhD work by first author Dongchen Du, we’ve developed a simple, byproduct-free labeling strategy using imidazopyridinium dyes formed in situ from isoquinolines!

onlinelibrary.wiley.com/doi/full/10....

#Fluorescence #Bioconjugation #ChemicalBiology #InSituLabeling