Exciting talk by Kevin Neumann (@neumannlab.bsky.social) at #NWOCHAINS. He talked about the tetrazine- and triazine-thiol exchange reactions for #bioconjugation and #peptide cyclization. He also discussed their potential application for #CovalentInhibitors.
onlinelibrary.wiley.com/doi/full/10....

Site‐Selective Peptide and Protein Functionalization with Cyclopropenium Cations A cysteine-selective bioconjugation using aromatic cyclopropenium cations is reported. The reaction proceeds rapidly under aqueous conditions, enabling site-selective installation of tetrasubstituted...

Interesting paper by the group of Marcos Suero in @angewandtechemie.bsky.social. They developed a #bioconjugation reaction to thiols using cyclopropenium cations. The resulting product on cysteine can be further modified using a thiol-ene reaction.

onlinelibrary.wiley....
#ChemSky #ChemBio

#research #bioconjugation #fluorescencelabeling

Thiosulfonate-Derived BODIPY “Stick and Glue” Strategy for Fluorescent Thiol Labeling
(Šálková, Dunlop, Tütüncü, Knejzlík, Slanina) – @angewandtechemie.bsky.social: doi.org/10.1002/anie...

@iocbprague.bsky.social @czechacademy.bsky.social

Syngene International Expands Bioconjugation Suite for ADC Development Expertise Syngene International is set to enhance its services with a new GMP bioconjugation suite, facilitating end-to-end antibody-drug conjugate development. This expansion will streamline drug development processes for biotech clients.

Syngene International Expands Bioconjugation Suite for ADC Development Expertise #India #Bengaluru #Bioconjugation #ADC_Development #Syngene_International

This study on β-ethoxy enone-based amine conjugation heralds a significant advancement in chemical biology and pharmaceutical sciences, providing a novel, efficient approach for modifying biologically relevant molecules.
doi.org/10.1016/j.xi...
#biocompatible #bioconjugation #chemicalbiology

Tetrahedron Chem | ScienceDirect.com by Elsevier - Tetrahedron Chem | ScienceDirect.com by Elsevier Read the latest articles of Tetrahedron Chem at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature

Call for Papers:

Tetrahedron Chem's special issue on Chemo-selective Transformation of Peptides and Proteins, co-guest edited by Dr. Kevin Neumann

www.sciencedirect.com/special-issu...

#peptidechemistry #proteinchemistry #bioconjugation

Chemoselective dual functionalization of proteins via 1,6-addition of thiols to trifunctional N-alkylpyridinium - Nature Communications Chemoselective dual functionalization of proteins is an invaluable tool to introduce two distinct payloads to proteins. Here, the authors present N-alkylpyridinium reagents as soft electrophiles for c...

Excited to share our latest research published in @natcomms.nature.com, where we explore a 1,6-addition of thiols to N-alkylpyridinium for site-selective dual modification of proteins. Congratulations to the team!
👉 www.nature.com/articles/s41...
#Bioconjugation
@seahling.bsky.social

An iridium(III) 3-chloro-6-thio-1,2,4,5-tetrazine complex for cysteine conjugation, bioimaging and photoactivated therapy - RSC Chemical Biology pubs.rsc.org/en/content/a... @bhkenlo.bsky.social & co-workers @rscchembio.rsc.org #iridium #tetrazine #cysteine #bioconjugation #imaging #PACT

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🔬 How Can #Nanobody #Bioconjugation Transform Breast Cancer Therapy?

🔹 Why does this matter?
Bioconjugated nanobodies combine target specificity with improved drug stability, making them a promising tool for next-generation cancer therapies.

📖 Read the complete study here: lnkd.in/gUyWyupQ

Beyond In Vivo, Pharmaceutical Molecule Production in Cell-Free Systems and the Use of Noncanonical Amino Acids Therein Throughout history, we have looked to nature to discover and copy pharmaceutical solutions to prevent and heal diseases. Due to the advances in metabolic engineering and the production of pharmaceutical proteins in different host cells, we have moved from mimicking nature to the delicate engineering of cells and proteins. We can now produce novel drug molecules, which are fusions of small chemical drugs and proteins. Currently we are at the brink of yet another step to venture beyond nature’s border with the use of unnatural amino acids and manufacturing without the use of living cells using cell-free systems. In this review, we summarize the progress and limitations of the last decades in the development of pharmaceutical protein development, production in cells, and cell-free systems. We also discuss possible future directions of the field.

New #publication is online in Chemical Reviews! Super stoked about our collaboration and explore #biotechnology #phamaceutical development, #unnatural amino acids, #cellfree and #bioconjugation. Enjoy!

pubs.acs.org/doi/10.1021/...

Synaffix and Illumina Forge Partnership for Metal-Free Click Chemistry in DNA Sequencing Synaffix has entered into a licensing agreement with Illumina to enhance DNA sequencing technology using its patented metal-free click chemistry, aiming for improved therapeutic applications.

Synaffix and Illumina Forge Partnership for Metal-Free Click Chemistry in DNA Sequencing #Netherlands #Amsterdam #Synaffix #Illumina #Bioconjugation

#Bioconjugation #chemistry is revolutionizing #materials #science! 🧪 Read the new Cluster #perspective by 1st author Christin Bednarek discussing the latest advances & new possibilities for #3Dprinting & biomedical applications: https://doi.org/10.1002/adfm.202303613 @braeselab...