Is CoA a problem because an over-constrictive (flow-sensitive) SMC subpopulation of CNC origin has invaded the aortic zone, which is supposed to be populated by mesodermal SMCs?😁

#CoarctationOfAorta
A developmental problem of #SmoothMuscleCell #BoundaryFormation?😃

"a border is formed at the interface b/w #CardiacNeuralCrest- derived SMCs in the 6th #PharyngealArchArtery & #ParaxialMesoderm -derived SMCs in the dorsal aorta"

#JDBMDPI 2025
www.mdpi.com/2221-3759/13...