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#CardiacNeuralCrest
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Is CoA a problem because an over-constrictive (flow-sensitive) SMC subpopulation of CNC origin has invaded the aortic zone, which is supposed to be populated by mesodermal SMCs?๐Ÿ˜

Is CoA a problem because an over-constrictive (flow-sensitive) SMC subpopulation of CNC origin has invaded the aortic zone, which is supposed to be populated by mesodermal SMCs?๐Ÿ˜

#CoarctationOfAorta
A developmental problem of #SmoothMuscleCell #BoundaryFormation?๐Ÿ˜ƒ

"a border is formed at the interface b/w #CardiacNeuralCrest- derived SMCs in the 6th #PharyngealArchArtery & #ParaxialMesoderm -derived SMCs in the dorsal aorta"

#JDBMDPI 2025
www.mdpi.com/2221-3759/13...

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Post image

Proximal Ascending aorta is made of #SmoothMuscleCell of dual lineage origins
Luminal side: Wnt1+ #CardiacNeuralCrest
Abluminal side: Mef2c+ #SecondHeartField

Their transcript profiles by scRNAseq + snATACseq๐Ÿ‘‡

#AortaEd
#ATVB 2024 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...

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