🔥Hot Off the Press | A study identifies #JMJD1C as a key regulator of tumor #Tregs, a promising selective cancer target.
🧐 Researchers identified #193D7, a potent inhibitor that suppresses #tumor growth without systemic autoimmunity, using the #AI platform #EquiScore.

This study reports that suppression of #Jmjd1c, driven by reduced recruitment of KLF15, downregulates #Socs3 via #H3K9 #Demethylation, leading to #NeuropathicPain, highlighting a key #Epigenetic mechanism in #disease development. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

New research!

Scientists demonstrate that KLF15 activates #Jmjd1c transcription, which in turn suppresses #NeuropathicPain degeneration through modulation of the Socs3/JAK/STAT3 signaling cascade, establishing a novel regulatory axis with promising therapeutic potential.

This study identifies #Jmjd1c as an essential suppressor in #NeuropathicPain (NP) by targeting the Socs3/JAK/STAT3 regulatory pathway and highlights it as a potential target for the treatment of NP. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Enhancer profiling uncovers Jmjd1c as an essential suppressor in neuropathic pain by targeting Socs3

This study identifies #Jmjd1c as an essential suppressor in #NeuropathicPain (NP) by targeting the Socs3/JAK/STAT3 regulatory pathway and highlights it as a potential target for the treatment of NP. #medsky

#OpenAccess: www.sciencedirect.co...