This study reports that suppression of #Jmjd1c, driven by reduced recruitment of KLF15, downregulates #Socs3 via #H3K9 #Demethylation, leading to #NeuropathicPain, highlighting a key #Epigenetic mechanism in #disease development. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

#SuperEnhancers (SEs) profiling in #NeuropathicPain (NP) reveals that Jmjd1c exerts an anti-NP effect via positively regulating #Socs3 expression by increasing H3K9 #demethylation and regulating the Jmjd1c/Socs3/JAK/STAT3 pathway.

#OpenAccess: www.sciencedirect.com/science/arti...