Epigenetics Update - Superenhancers shape the landscape and repair dynamics of transcription-associated DNA breaks in cancer bit.ly/3NUCrtY

Rami I. Aqeilan reporting in Sci Adv

#Epigenetics #Superenhancers #Cancer #DNAdamage
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Discover the breakthrough at epigenometech.com

Our findings also point to transcriptional addiction as a cancer-specific vulnerability.

Huge congratulations to Osama for his perseverance and outstanding work, and to all co-authors for this collective achievement.

#ScienceAdvances #CancerResearch #GenomicInstability #DNARepair #SuperEnhancers

#SuperEnhancers (SEs) profiling in #NeuropathicPain (NP) reveals that Jmjd1c exerts an anti-NP effect via positively regulating #Socs3 expression by increasing H3K9 #demethylation and regulating the Jmjd1c/Socs3/JAK/STAT3 pathway.

#OpenAccess: www.sciencedirect.com/science/arti...

E-box independent chromatin recruitment turns MYOD into a transcriptional repressor MYOD is an E-box sequence-specific basic Helix-Loop-Helix (bHLH) transcriptional activator that, when expressed in non-muscle cells, induces nuclear reprogramming toward skeletal myogenesis by promoti...

New Preprint from Puri lab and first co-corresponding manuscript for me!
Big thanks to all the collaborators.

#transcription #myoskeet #myogenesis #3Dgenome #superenhancers

a skeetorial will come soon :) now it is time to celebrate!!! 🥳

www.biorxiv.org/content/10.1...