This study reports that suppression of #Jmjd1c, driven by reduced recruitment of KLF15, downregulates #Socs3 via #H3K9 #Demethylation, leading to #NeuropathicPain, highlighting a key #Epigenetic mechanism in #disease development. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Microbial Physiological Adaptation to Biodegradable Microplastics Drives the Transformation and Reactivity of Dissolved Organic Matter in Soil The turnover of dissolved organic matter (DOM) in soil regulated by biodegradable microplastics (MPs) has garnered much attention due to its profound impact on the storage and stability of soil organic matter. However, the transformation and reactivity of plant-derived and microbially derived DOM by microorganisms adapted to biodegradable MPs, and the involved microbial physiological processes, remain nearly unknown. Here, we added virgin and aged polylactic acid (PLA) and polyhydroxyalkanoate (PHA) to agricultural soils and incubated for 56 days. Using stable isotope techniques, reactomics, and metagenomics, we found that the addition of both virgin and aged PLA induced hydroxylation, demethylation, and dehydrogenation of lignin-derived DOM, resulting in a 3-fold increase in their oxidation degree. PLA activated the enzymatic pathway for lignin-derived DOM decomposition and downregulated genes involved in bacterial anabolism, such as those related to protein, amino sugar, and peptidoglycan biosynthesis. In contrast, PHA increased the content of microbially derived DOM compounds such as proteins and amino sugars by 2.1-fold relative to the control with peptide chain elongation. PHA resulted in the degradation of lignin-derived DOM into pyruvate and acetyl-CoA, accelerated bacterial ATP synthesis, the de novo biosynthesis of proteins and peptidoglycan, and cell renewal and death, thereby increasing PHA- and soil organic matter-derived microbial necromass carbon. Our study provides new insights into the impact of biodegradable MPs on soil DOM transformation and underscores the importance of the microbial physiological processes involved.

NEW in Environmental Science & Technology

Microbial Adaptation to Biodegradable #Microplastics Drives Transformation & Reactivity of Dissolved Organic Matter in #Soil

doi.org/10.1021/acs....

#soilbacteria #Environment #isotopes #reactomics #metagenomics #demethylation #dehydrogenation

A comprehensive summary of the #Epigenetic role of the ten-eleven translocation 1 (TET1) protein, a crucial mediator of #demethylation in the clinical progression of various #cancers and other clinical diseases/disorders. #medsky
#OpenAccess:

#SuperEnhancers (SEs) profiling in #NeuropathicPain (NP) reveals that Jmjd1c exerts an anti-NP effect via positively regulating #Socs3 expression by increasing H3K9 #demethylation and regulating the Jmjd1c/Socs3/JAK/STAT3 pathway.

#OpenAccess: www.sciencedirect.com/science/arti...

DNA demethylation explains how tomatoes convert their bitter toxins into something more palatable A multi-institutional team of bioengineers has identified the genetic mechanism that converts bitter toxins to palatable compounds in tomatoes. In their study published in the journal Science Advances...

#DNA #demethylation explains how #tomatoes convert their bitter #toxins into something more palatable.

#gene_expression #physalis #agriculture #solanaceae #glycoalkaloid #epigenetic

phys.org/news/2025-02...

TET1: The epigenetic architect of clinical disease progression

A summary on the #Epigenetic role of ten-eleven translocation 1 (TET1) protein, a crucial mediator of #demethylation in the clinical progression of various #cancers and other clinical diseases/disorders.

#OpenAccess: https://buff.ly/3PAQnah

We just made the #biocatalytic #demethylation using cobalamin dependent enzymes a lot more straight forward by fusing the two required enzymes. Congratulations to the authors Chris, @simona_pompei, Kristina, Michi and @WKroutil. Enjoy reading! ...