#KZFPs typically function through establishment of #heterochromatin, via interactions with KAP1/Trim28.
However:
- ZKSCAN3 doesn't bind KAP1
- ZKSCAN3 modulation does not affect H3K9me3
- The KRAB-deletion mutant rescues ZKSCAN3 function as well as the wild-type.
#KZFPs consist the largest family of transcription factors in most mammals and are well known for keeping #transposons in check.
Here, we found that ZKSCAN3 targets #enhancers containing 'domesticated' #transposons, limit their accessibility and suppresses their function.
ZKSCAN3 belongs to a sub-family of #KZFPs that contain a poorly characterised SCAN domain. It is of particular interest as it exhibits strong genetic association with #schizophrenia risk.
