Scientists report that limited #TACE-induced #necrosis predicts post-transplant #HepatocellularCarcinoma recurrence, revealing a hypoxia-driven HIF-1α/LGR5/MAPK axis that boosts metastasis & positions #LGR5 as a key #biomarker and therapeutic target.
#OpenAccess: doi.org/10.1016/j.ge...
Opening the #CRKI @ki.se retreat in #Djurönäset with a keynote by @hansclevers.bsky.social not only on #LGR5 and #organoids but #PacMan behavior of #Car-T cells killing tumor cells with lasso etc.
Full House w/ more than 260 cancer researchers!
New preprint!
We mapped the clonal architecture of mouse and human intestine using DNA barcoding, revealing key species-specific differences. Lessons from mice don’t always translate to humans!
biorxiv.org/content/10.110…. #StemCell #Barcoding #CRISPR #pISC #TOB2 #LGR5 #ASCL2
My paper is out! A cool little story that spun out of a completely unexpected observation #OA #Lgr5 #neuroscience
www.plosone.org/article/info:doi/10.1371...
