Glucose tasting depletes intracellular calcium stores and impairs macrophage functionality Hyperglycemia or increased blood glucose concentrations is a characteristic and one of the diagnostic criteria for Diabetes mellitus and critically co…

Glucose tasting depletes #intracellular #calcium stores and impairs #macrophage functionality #iSicence #BurgdorfLab #KiermaierLab #LangLab #KolanusLab @masslab.bsky.social @unibonn.bsky.social @immunosens.bsky.social #Cell #biology; #Health #sciences; #Immunology shorturl.at/Fahb3

FEBS Press The tetraspanin CD9 has an intracellular salt bridge. If CD9 opens, open-CD9 moves from PIP2-rich areas to regions populated by its interaction partner EWI-2. Hence, the state of the salt bridge regu...

CD9-association with PIP2 areas is regulated by a CD9 salt bridge. #FEBSopenbio #LangLab @unibonn.bsky.social #EWI‐2; #second messengers; #signaling; #tetraspanin‐enriched #microdomains. shorturl.at/8cObV

Don't forget: Cauldron is THIS THURSDAY @ LangLab South Bend! Join us for dark tunes and good times!

#cauldronsouthbend #cauldrondarkalternative #freezeetch #djplaguemd #langlab #langlabsouthbend #goth #industrialmusic #postpunk #techno #synth #darkwave #southbendmusic #southbendmusicscene

HSPG-binding peptide Pep19-2.5 is a potent inhibitor of HPV16 infection | Antimicrobial Agents and Chemotherapy Antiviral peptides have emerged as promising therapeutic targets against a wide range of DNA and RNA viruses, including cytomegalovirus (CMV), herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), adenovirus, rotavirus, poliovirus, respiratory syncytial virus (RSV), human immunodeficiency virus (HIV), influenza virus, hepatitis B virus (HBV), hepatitis C virus (HCV), and the dengue, chikungunya, and Zika viruses, targeting various stages of viral infection (1). A novel class of inhibitors known as synthetic anti-lipopolysaccharide peptides (SALPs) has been suggested as suitable broad-spectrum antiviral and anti-inflammatory agents as they exhibit low cytotoxicity and effectively block the attachment, and as a result, the infection of human pathogenic viruses (2, 3). Among these inhibitors, Peptide 19-2.5 (also known as Aspidasept or Pep19-2.5) has attracted attention for its ability to inhibit the entry of various enveloped viruses, including hepatitis B, hepatitis C, and human immunodeficiency virus (3). This is achieved through its binding to heparan sulfate proteoglycans (HSPGs) and sialic acids on the plasma membrane. Studies suggest that the positively charged amino acids within Pep19-2.5 compete with the virus for the binding to the negatively charged plasma membrane components (2, 3). In addition, it has been demonstrated that Pep19-2.5 possesses anti-septic properties in vitro and in vivo by reducing the production of pro-inflammatory cytokines (4, 5). The influence of Pep19-2.5 on non-enveloped viruses has not been investigated so far.

HSPG-binding peptide #Pep19-2.5 is a potent inhibitor of #HPV16 #infection; #AntimicrobAgentsChemother #LangLab @unibonn.bsky.social #UnimedizinMainz #Aspidasept; #SALP; #human #papillomavirus shorturl.at/Qc30l

Deeply grateful for this collaborative team of dedicated researchers and scientists seeking to do better in our shared fight against cancer. New data and trials on the way! @theaacr.bsky.social @helloeacr.bsky.social #Langlab #Sharifilab #CirculatingBiomarkerCore

me on stage with green lasers

Scott brooding in purple

me singing in blue

Scott punishing that keyboard

we're in #chicago tonight at #undergroundlounge & tomorrow night at #langlab #southbend come through! #solemnshapes