Rahul K

@theresearch.bsky.social

3 days ago

Bioproduction, bioprotection, and biocontainment in multi-Kingdom microbial systems with 3D spatial control Bioproduction, bioprotection, and biocontainment in multi-Kingdom microbial systems with 3D spatial control, Le, LeAnn, Altin-Yavuzarslan, Gokce, Klatt, Elizabeth C, Sadaba, Naroa, Berg, Angus C, Karanjia, Ava V, Brooks, Sierra M, Zalatan, Jesse G, Pozzo, Lilo D., Carothers, James, Alper, Hal S, Nelson, Alshakim

Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/...
via @biomednews.bsky.social | #livingmaterials #ELMs

includes research on: multi-kingdom microbial systems, conductive hydrogels for sense and respond, innovating biomanufacturing with coculture-based ELMs & more 🧪

Sarah Schyck

@sschyck.bsky.social

1 week ago

🍄 My latest work with @shapingmatterlab.bsky.social is officially out in Advanced Functional Materials. We used mycelium & 3D printing to create some beautiful materials.

Check out the paper now: doi.org/10.1002/adfm...

#3dprinting #livingmaterials #mycelium

Rahul K

@theresearch.bsky.social

1 week ago

Micropatterned DNA Hydrogels for Spatiotemporal Programming of Chemical Reaction Networks Cells in living systems communicate by sending and receiving signal molecules to coordinate their behavior. To achieve long-distance and noise-resistant communication, cells pattern themselves into sp...

Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/...
via @biomednews.bsky.social | #livingmaterials #ELMs

includes research on: micropatterned DNA hydrogels, & synthetic aptamer mechanoreceptors (h/t @waltherlab.bsky.social ), circuits for cell ratio control & more 🧪

Rahul K

@theresearch.bsky.social

2 weeks ago

Delivering living medicines with biomaterials - Nature Reviews Materials As the field of engineered therapeutic living cells advances, new strategies to deliver them into the body are needed. This Review identifies current challenges in living medicine delivery and discuss...

Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/...

via @biomednews.bsky.social | #livingmaterials #ELMs

includes research on: stress-relaxing granular bioprinting, delivering living medicines with biomaterials (h/t tetsuharimoto.bsky.social), & more 🧪

Rahul K

@theresearch.bsky.social

3 weeks ago

The Intersecting Physical Mechanisms That Regulate Cell Viability in 3D Synthetic Hydrogels This study coordinates multiple cell-biomaterial interfaces to evaluate the overlapping physical signals of stiffness, solute transport, and cell confinement presented when cells are encapsulated in ...

Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/...

via @biomednews.bsky.social | #livingmaterials #ELMs

includes research on: tough hydrogels enabled by transient entanglements, physical mechanisms that regulate cell viability in 3D synthetic hydrogels, & more 🧪

Rahul K

@theresearch.bsky.social

3 weeks ago

Ultrafast-relaxing and photopolymerizable PEG hydrogels enable viscoelasticity-mediated cell remodeling in synthetic matrices Photopolymerizable BELA hydrogels combine dynamic boronate ester and elastic dithiolane-ene crosslinks to achieve ultrafast stress relaxation and tunable viscoelasticity. By adjusting formulation and ...

Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/...

via @biomednews.bsky.social | #livingmaterials #ELMs

includes research on: cell remodeling in synthetic matrices, designing self-healing, printable, and tough conductive hydrogels, matter and microbes & more 🧪

Rahul K

@theresearch.bsky.social

1 month ago

Conformation-programmed DNA computing This DNA computing model integrates sequence programmability with allostery, establishing a conformation-based computing paradigm.

Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/...

via @biomednews.bsky.social | #livingmaterials #ELMs

includes research on: macroscopic cell-Laden cryogels., 4D morphogenetic tissue engineering, conformation-programmed DNA computing & more 🧪

Rahul K

@theresearch.bsky.social

1 month ago

Sub-second volumetric 3D printing by synthesis of holographic light fields - Nature A new method is described that uses a periscope to generate high-speed, high-resolution projections of light fields, enabling sub-second volumetric 3D printing of millimetre-scale objects without rota...

Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/...

via @biomednews.bsky.social #livingmaterials #ELMs

includes research on: sub-second volumetric 3D printing, fluorescently labeled gradient hydrogels, learning nature's assembly language with polymers & more 🧪

Technische Universität München

@tum.de

1 month ago

Living material makes harmful UV-light visible Researchers at TUM have developed a coating that reliably indicates exposure to UVA radiation. It could pave the way for further living materials.

Scientists developed a functional coating made of #proteins and #bacteria, that detects contact with UV-A radiation, is bio based, and could offer new perspectives for the development of #livingmaterials: go.tum.de/923111

#biotechnology #sustainability

📷A. Eckert

Rahul K

@theresearch.bsky.social

1 month ago

Light-powered bacteria become living chemical factories Engineered Escherichia coli could open the door to more sustainable routes to new drugs and other chemicals.

Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/...

via @biomednews.bsky.social #livingmaterials #ELMs

includes research on: living chemical factories, acoustic shape-morphing micromachines, higher performance artificial muscles, ecological Catch-22, & more 🧪

Rahul K

@theresearch.bsky.social

1 month ago

Additive Manufacturing of Metabolically Active Living Materials with Physicochemical Biocontainment @chemrxiv.org
#ELMs #livingmaterials #MALM
chemrxiv.org/doi/full/10....

Rahul K

@theresearch.bsky.social

2 months ago

Artificial Symbiosis for Bulk Production of Bacterial Cellulose Composites Co-cultivation of the cellulose-producing bacterium with the microalga enables bulk formation of bacterial cellulose under static incubation, with photosynthetically active oxygen-generating sites th...

Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/...

via @biomednews.bsky.social #livingmaterials #ELMs

includes research on: bacterial cellulose composites (h/t @proftomellis.bsky.social, @vignolinilab.bsky.social), living bioelectronics devices, & more 🧪

Rahul K

@theresearch.bsky.social

2 months ago

Light-Responsive Protein Hydrogels Bridge Molecular Mechanics and Frequency-Dependent Mechanotransduction Dynamic extracellular matrix mechanics regulate fundamental cellular processes, yet precise control over spatiotemporal rigidity modulation remains challenging. Protein-based photoresponsive hydrogels...

Latest issue of curated #engineeredlivingmaterials feed:

biomed.news/bims-enlima/...

via @biomednews.bsky.social #livingmaterials #ELMs

includes research on: remote controlled proteins, volumetric bioprinting, light-responsive protein hydrogels, biocatalytic surfaces in architecture, & more 🧪

Rahul K

@theresearch.bsky.social

2 months ago

PSA🚨 #GRC on Additive Manufacturing of Soft Materials

Pls RT: h/t @dryeeseeks.bsky.social, @blascolab.bsky.social, @coledeforest.bsky.social

#additivemanufacturing #softmaterials #3Dprinting #ELMs #livingmaterials

Rahul K

@theresearch.bsky.social

2 months ago

Electrogenic protein condensates as intracellular electrochemical reactors - Nature Materials Protein condensates are engineered with tunable interfacial electric fields to drive electrochemical reactions, serving as a biomaterial platform for intrinsic electrogenic materials.

Latest issue of curated #engineeredlivingmaterials feed:

biomed.news/bims-enlima/...

via @biomednews.bsky.social #livingmaterials #ELMs

includes research on: electrochemical reactors, supramolecular hydrogels, transcriptome storage in mammalian cells & more🧪

Rahul K

@theresearch.bsky.social

3 months ago

Genetically Encoded SpyTag Enables Modular AAV Retargeting via SpyCatcher-Fused Ligands for Targeted Gene Delivery Recombinant adeno-associated viral (rAAV) vectors are a leading platform for in vivo gene therapy, valued for their excellent safety, broad serotype diversity, and scalable production. Targeted delivery through capsid display of ligands holds great promise, yet current retargeting strategies often rely on extensive capsid re-engineering and restrict the use of ligands incompatible with intracellular expression systems. Here, we present a modular AAV retargeting platform that, for the first time, employs the SpyTag/SpyCatcher system via genetic integration into the AAV2 capsid. SpyTag is a small peptide that forms a covalent, irreversible bond with its protein partner, SpyCatcher, allowing site-specific ligand coupling under physiological conditions. Inserting SpyTag into surface-exposed capsid sites enabled postassembly functionalization of AAVs with SpyCatcher-fused targeting proteins. As proof of concept, we used SpyCatcher fusions with designed ankyrin repeat proteins (DARPins) specific for EGFR, EpCAM, and HER2. This conferred highly specific transduction of corresponding cancer cell lines with minimal off-target activity. Therapeutic potential was demonstrated by delivering a suicide gene, inducing selective cancer cell killing upon prodrug administration. This “one-fits-all” platform allows rapid and flexible retargeting without significantly altering the underlying vectors genome or production process. It supports the incorporation of large or complex ligands not amenable to genetic fusion and facilitates high-throughput preclinical evaluation strategies. By uniting capsid engineering with modular ligand display, our approach provides a scalable and versatile framework for precision gene delivery, broadening the applicability of rAAV in both therapeutic and discovery settings.

Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/... #ELMs
via @biomednews.bsky.social #livingmaterials

includes research on: designing synthetic regulatory elements, ligands engineering for targeted gene delivery (h/t @wilfriedweber.bsky.social), & more🧪

Rahul K

@theresearch.bsky.social

3 months ago

MultiCell: geometric learning in multicellular development - Nature Methods MultiCell is a deep learning method to capture complex cell dynamics during multicellular development.

Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/... #ELMs
via @biomednews.bsky.social #livingmaterials

includes research on: protein waves in living cells, geometric learning in multicellular development &more🧪

Merry Christmas and Happy Happy Holidays 🎄🎅 🥳

Rahul K

@theresearch.bsky.social

3 months ago

Biomaterial-minimalistic photoactivated bioprinting of cell-dense tissues We developed a bioprinting strategy that turns living cells into cell-only bioinks, enabling light-based 3D bioprinting of tissues at native, ultrahigh cell densities (up to ∼109 cells mL−1) to rapidl...

Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/... #ELMs
via @biomednews.bsky.social #livingmaterials

includes research on: bioprinting minimalism (h/t @cellpress.bsky.social) , programmable death of artificial cell, electrogenic living hydrogels, & more 🧪

Rahul K

@theresearch.bsky.social

3 months ago

Design principles for adaptive and evolving engineered living materials Engineered living materials (ELMs) combine living cells, typically microorganisms, such as bacteria, yeasts, or filamentous fungi, with structural car…

Design principles for adaptive and evolving engineered living materials #ELMs #livingmaterials

Rahul K

@theresearch.bsky.social

3 months ago

Synthetic cells by the numbers Mathematical biosciences; Experimental models in systems biology; Synthetic biology

Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/... #ELMs
via @biomednews.bsky.social #livingmaterials

includes research on: synthetic cells, ELMs design principles, muscle-powered robots, & more 🧪

Rahul K

@theresearch.bsky.social

4 months ago

Acoustic printing of conductive polymers | PNAS Fabricating materials within optically opaque structures, such as biological tissue, is a considerable challenge. Recently, ultrasound-based printi...

Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/... #ELMs
via @biomednews.bsky.social #livingmaterials

includes research on: acoustic printing of conductive polymers, fungal ELMs, DNA origami membranes, & more 🧪

Rahul K

@theresearch.bsky.social

4 months ago

3D necroprinting: Leveraging biotic material as the nozzle for 3D printing Dead mosquitoes find new life as ultrafine 3D printer nozzles, enabling sustainable microscale manufacturing.

Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/... #ELMs
via @biomednews.bsky.social #livingmaterials

includes research on: 3D necroprinting, self-assembling protein materials, directed self-assembly of 3D interconnected networks & more 🧪

Rahul K

@theresearch.bsky.social

4 months ago

Increasing the dimensionality of transistors with #hydrogels

#ELMs #livingmaterials

Rahul K

@theresearch.bsky.social

4 months ago

A molecularly impermeable polymer from two-dimensional polyaramids - Nature Two-dimensional polyaramid polymers are synthesized to form nanofilms that exhibit the lowest gas permeability of any polymer by orders of magnitude, despite lacking crystallinity, enabling molec...

Latest issue of curated #engineeredlivingmaterials feed:
biomed.news/bims-enlima/... #ELMs
via @biomednews.bsky.social #livingmaterials

includes research on: molecularly impermeable polymer, , soft photoresponsive hydrogel, pollen-inspired biopolymer-based multifunctional films, & more 🧪

Rahul K

@theresearch.bsky.social

5 months ago

Programming cellular condensates for living materials using an intrinsically disordered protein display platform | PNAS Self-organization underpins the emergence of complex structure in living systems but remains a major challenge for engineering synthetic multicellu...

Programming cellular condensates for living materials using an intrinsically disordered protein display platform #livingmaterials

Rahul K

@theresearch.bsky.social

5 months ago

Bacterially grown living materials with resistant and on-demand functionality Resilient bacterial cellulose–based living materials store dormant spores, awakening to deliver programmable functions.

Bacterially grown #livingmaterials with resistant and on-demand functionality

Jacky Kapadia

@jacky1986.bsky.social

8 months ago

Living 3D Material: A Smart, Breathable Innovation That Captures CO₂ The relentless rise of atmospheric CO₂ levels demands solutions that are not just effective, but scalable, sustainable, and ideally…

Living 3D Material: A Smart, Breathable Innovation That Captures CO₂

#CarbonCapture #LivingMaterials #ClimateTech #SustainableInnovation #FutureOfEnergy

medium.com/p/living-3d-...

Jessica Schiffman

@schiffmanlab.bsky.social

8 months ago

Harnessing Biofilm-Mediated Plastic Biodegradation: Innovating Smart Material Design The persistent environmental challenges posed by synthetic plastics, particularly petroleum-derived petropolymers, such as polyethylene (PE), polypropylene (PP), and polystyrene (PS), have intensified...

Fresh ASAP in ACS Applied Engineering Materials - Open Access Review from Dr. Huan Gu @ Univ of New Haven:

Harnessing Biofilm-Mediated Plastic Biodegradation: Innovating Smart Material Design

pubs.acs.org/doi/10.1021/...
@acs.org @pubs.acs.org #livingmaterials

Today's tech

@sk31612.bsky.social

9 months ago

20/ ❤️ If you’re into sustainability, biotech, or just cool future‑tech, follow for more deep dives like this—no fluff, just future.

#CarbonCapture #LivingMaterials #3DPrinting #Sustainability #Innovation