Greenebaum Family Donates $5.5 Million to Advance Cancer Research and Patient Care The Marlene and Stewart Greenebaum Family Foundation has donated $5.5 million to the University of Maryland Greenebaum Comprehensive Cancer Center (UMGCCC) to help advance groundbreaking scientific re...

We are extremely grateful for the Greenebaums’ generous gift and for their steadfast support of UMGCCC over the last three decades!

#MedSky #MedEd #Cancer #Research

University of Maryland School of Medicine announces Greenebaum family's $5.5 million donation to advance cancer research and patient care at UMGCCC.

Photo of Michael Greenebaum in a suit jacket against a blurred autumn backdrop, paired with a message about legacy and cancer research commitment.

A $5.5M gift from the Marlene and Stewart Greenebaum Family Foundation will accelerate cancer research and care at UMGCCC—supporting innovations like CAR T‑cell therapy for solid tumors and expanding survivorship programs across Maryland.

#MedSky #MedEd #CancerResearch #Oncology #CancerCare

Pharma and AI Partnering to Drive New Era in Antibiotic Development | Contagion Live In the second episode of this short series, Akhila Kosaraju, MD, talks about how Phare Bio and Basilea Pharmaceuticals are partnering to develop antimicrobials taking them from AI molecules to clinica...

In the second episode of this short series, Akhila Kosaraju, MD, talks about how Phare Bio and Basilea Pharmaceuticals are partnering to develop antimicrobials taking them from AI molecules to clinical trials. #IDsky #Medsky

www.contagionlive.com/view/pharma-...

#MedSky

Test Your Knowledge About the Care Team for HAE - Rare Disease Advisor Test your knowledge about the care team for HAE with this short quiz and see how your responses compare to those of others.

🧠 How well do you know the #HAE care team?

Put your knowledge of #HereditaryAngioedema to the test with this quick quiz and see how your answers stack up against others.

👉 Take the quiz: https://bit.ly/4t2Ncua

💬 Drop your score in the comments!

#RareDisease #MedSky #MedicalQuiz

18/
🧠 Take-home:

tGFR is a promising step toward making measured GFR clinically usable.
But it may not be ready for routine use yet, given the lack of validation against gold-standard mGFR and technical issues that could affect real-world reliability.

#NephSky
#MedSky

16/ Is a 30% margin (P30) acceptable when we’re dosing chemo or nephrotoxins?
⁉️How would this perform in real patients - AKI, ICU, Edema, paeds?
⁉️Are we ready to move from a $10 creatinine test → device + tracer-based system?
Accuracy is one thing. Adoption is a different battle.
#MedSky

9/ 📚 Study basics:
Prospective, multicenter (US + China)
n = 182
GFR range: normal → CKD stage 4 (Stratified into eGFR > 70, and <15-60)
Compared tGFR vs plasma-measured GFR (nGFR)
Primary endpoint: P30 accuracy ⇒ % of tGFR values within 30% of the nGFR

#NephSky
#MedSky

3/ If a reliable, bedside measured GFR modality (no blood sampling) is available, how would you use it?
A) Replace eGFR in most patients
B) Use in selected high-risk cases only
C) Nice idea, but impractical
D) Not convinced it adds value
Do reply in chat!!
#NephSky #MedSky

2/ Our #Skytorial is by Akshaya Jayachandran, @nephromommy-akshu.bsky.social, adult nephrologist from India - No COI 👩‍⚕️

#MedSky #nephSky

Check out #KIReportsCommunity educational #blogposts at www.kireportscommunity.org.

FOLLOW US at @kireports.bsky.social

#EHJCVI 📊 EKSTROM trial: at 1 year, colchicine 0.5 mg/day did not reduce low-attenuation plaque, but slowed progression of total plaque burden on CCTA, highlighting a potential role in modulating plaque progression #yesCCT 🔗 Read more -> doi.org/10.1093/ehjc... #MedSky

1/13 🩺 CANCER CARE ENTERS A SCIENCE FICTION ERA 🩺

BBC's Jamie Ducharme reports on Maureen, whose tumour vanished in four months without chemo.

The secret? Unmasking cancer to the immune system.

#MedSky #Oncology #BioTech #CancerCare #Immunotherapy

Is long COVID forever? A new study has clues. Research hints that those with symptoms may see an improvement after two years—but not everyone.

Is long COVID forever? A new study has clues.

www.nationalgeographic.com/premium/arti...

#News #WorldNews #Science #Research #Health #PublicHealth #Medical #MedSky #COVID #COVID19 #Coronavirus #Body #LongCovid

America’s First Amphetamine Epidemic 1929–1971: A Quantitative and Qualitative Retrospective With Implications for the Present Using historical research that draws on new primary sources, I review the causes and course of the first, mainly iatrogenic amphetamine epidemic in the United States from the 1940s through the 1960s. ...

4. There is a great history of #amphetamines here, with a phrase that sticks.

Amphetamines help certain patients with "managing their problems of living" #medsky

pmc.ncbi.nlm.nih.gov/articles/PMC...

COVID-19 has tested us. Will we be ready for the next pandemic? An infectious disease expert with insider access gives his take on what we did well, what we need to fix, and how to prepare for future outbreaks.

COVID-19 has tested us. Will we be ready for the next pandemic?

www.nationalgeographic.com/science/arti...

#News #WorldNews #Science #Research #Health #PublicHealth #Medical #MedSky #COVID #COVID19 #Coronavirus #Pandemic #InfectiousDiseases #Outbreak

Multiple COVID infections can lead to chronic health issues. Here’s what to know. A previous SARS-CoV-2 infection can protect you for a little while, but the immunity wanes—and each new infection, no matter how mild, takes a toll on your body.

Multiple COVID infections can lead to chronic health issues. Here’s what to know.

www.nationalgeographic.com/premium/arti...

#News #WorldNews #Science #Research #Health #PublicHealth #Medical #MedSky #COVID #COVID19 #Coronavirus #Body #Organs #Vaccines #CovidVaccines

RFK And Dr. Oz Want Anti-Marijuana Groups' Lawsuit Challenging Medicare Hemp Coverage Program Dismissed - Marijuana Moment Federal health officials are asking a court to dismiss marijuana legalization opponents’ lawsuit challenging a new Trump administration initiative to cover up to $500 worth of hemp-derived products ea...

HHS seeks dismissal of suit challenging its Medicare coverage of certain cannabis products.

#Medsky #geriatrics #primarycare #marijuana #THC #CBD #pain #internalmedicine #familymedicine #healthlaw #healthpolicy

Improving Order-Entry Competency: A new study examines stakeholder perspectives on order entry to identify educational gaps and inform curriculum development: https://bit.ly/4t2ql1R #MedEd #MedSky

Discover Medicine

A study in Discover Medicine uses single-cell RNA sequencing to explore the immune landscape in chronic antibody-mediated rejection in kidney transplants, identifying key inflammatory pathways for future diagnostics and therapies.
bit.ly/3Q78tnN

#MedSky

How doctors are suddenly diagnosing adults with ADHD It used to be a childhood disease. Now researchers are discovering that symptoms of the disorder seem to shift as we get older. What does that mean for people already struggling with a world of distra...

How doctors are suddenly diagnosing adults with ADHD

www.nationalgeographic.com/health/artic...

#News #WorldNews #Science #Research #Health #Healthcare #Medical #MedSky #ADHD #MentalHealth #AdultADHD

Dexamyl · American Institute of the History of Pharmacy Digital Collection Collections from the American Institute of the History of Pharmacy. and the University of Wisconsin–Madison School of Pharmacy.

3. #Dexamyl was a favorite of British Mods (see Quadrophenia). Also was prescribed to British PM Anthony Eden, Jerry Lee Lewis, Pete Rose and Terry Southern

aihp.omeka.net/items/show/816 #medsky

2. #Dexamyl was marketed as an appetite suppressant, with the barbiturate providing some relief from the side effects of the amphetamine

Its manufacturing was discontinued in 1982.

#medsky

1. Going back into the history of The Who and came across the pharmacological nightmare that is #Dexamyl

Who thought it was a good idea to combine a barbiturate with an amphetamine? Dex-troamphetamine + amylbarbitone = De samyl #medsky

Jerome Adams-when you consider smallpox, polio, and the empires that have been brought down by infectious diseases, vaccines are the greatest & most lifesaving medical achievement in human history. Destroying public confidence in them is not how you make anyone or any nation healthy.

#medsky

Peripheral Frataxin Levels Predict Long-Term Clinical Outcomes in Friedreich Ataxia Results of a prognostic modeling study support peripheral frataxin quantification as a surrogate endpoint in clinical trials.

Peripheral #Frataxin levels predict long-term clinical outcomes in #FriedreichAtaxia (FA), supporting their use as a biomarker of disease severity and progression, as described in BMJ Neurology Open.

Learn more: https://bit.ly/4v8A2Nw

#RareDisease #Neurology #MedSky

SARS-CoV-2 and its Multifaceted Impact on Bone Health: Mechanisms and Clinical Evidence SARS-CoV-2 infection, the culprit of the COVID-19 pandemic, has been associated with significant long-term effects on various organ systems, including bone health. This review explores the current und...

Curr Osteoporos Rep. 2024 Jan 18;22(1):135–145.
doi: 10.1007/s11914-023-00843-1

SARS-CoV-2 and its Multifaceted Impact on Bone Health: Mechanisms and Clinical Evidence

pmc.ncbi.nlm.nih.gov/articles/PMC...

#SARSCoV2
#medsky
#bonesky

Curr Osteoporos Rep. 2024 Jan 18;22(1):135–145. doi: 10.1007/s11914-023-00843-1 SARS-CoV-2 and its Multifaceted Impact on Bone Health: Mechanisms and Clinical Evidence Alexander Harris 1, Amy Creecy 1, Olatundun D Awosanya 1, Thomas McCune 2,3, Marie V Ozanne 4, Angela J Toepp 2,5, Melissa A Kacena 1,6,✉, Xian Qiao 2,7,8,✉ Author information Article notes Copyright and License information PMCID: PMC10912131 PMID: 38236510 Abstract Purpose of Review SARS-CoV-2 infection, the culprit of the COVID-19 pandemic, has been associated with significant long-term effects on various organ systems, including bone health. This review explores the current understanding of the impacts of SARS-CoV-2 infection on bone health and its potential long-term consequences. Recent Findings As part of the post-acute sequelae of SARS-CoV-2 infection, bone health changes are affected by COVID-19 both directly and indirectly, with multiple potential mechanisms and risk factors involved. In vitro and preclinical studies suggest that SARS-CoV-2 may directly infect bone marrow cells, leading to alterations in bone structure and osteoclast numbers. The virus can also trigger a robust inflammatory response, often referred to as a "cytokine storm", which can stimulate osteoclast activity and contribute to bone loss. Clinical evidence suggests that SARS-CoV-2 may lead to hypocalcemia, altered bone turnover markers, and a high prevalence of vertebral fractures. Furthermore, disease severity has been correlated with a decrease in bone mineral density. Indirect effects of SARS-CoV-2 on bone health, mediated through muscle weakness, mechanical unloading, nutritional deficiencies, and corticosteroid use, also contribute to the long-term consequences. The interplay of concurrent conditions such as diabetes, obesity, and kidney dysfunction with SARS-CoV-2 infection further complicates the disease's impact on bone health

In SARS-CoV-2 ... in addition to lower muscle mass, long-term consequences of SARS-CoV-2 infection include decreased exercise capacity and chronic fatigue impairing daily activities, all of which have an indirect impact on bone health [94]. Taken together, SARS-CoV-2 has both immediate and long-term effects on muscle mass and daily activities, raising concerns for additional mechanisms of bone health deterioration in PASC patients. Further research is needed to fully understand these relationships and develop effective interventions. Nutritional Deficiencies and their Impact on Bone Health in the Context of SARS-CoV-2 Infection SARS-CoV-2 patients often experience nutritional challenges, including malnutrition and significant weight loss, which can impact bone health [95, 96]. Vitamin D3, or cholecalciferol, has been associated with the regulation of bone, calcium, and phosphorus metabolism, as well as the modulation of the immune system [97]. Its deficiency may lead to immune dysregulation, including impaired macrophage function and increased production of proinflammatory cytokines [98], leading to indirect effects on bone health. Zinc and selenium deficiencies have been positively associated with the incidence of SARS-CoV-2 infection and zinc deficiencies have been associated with the severity of disease, highlighting their role in immune modulation and antiviral capabilities [99]. Zinc, in particular, can regulate the RANKL/RANK/OPG pathway, a crucial axis for bone remodeling [100]. Selenium affects bone health via its regulation in the production of pro-inflammatory cytokines [101]. However, a systematic review found few studies investigating selenium supplementation and that the zinc supplementation studies did not provide evidence for efficacy in prevention or as a therapeutic for SARS-CoV-2 infection, indicating a need for further investigation and caution in utilizing supplementation as an approach for treating COVID-19 patients.

Notice how many young people who need hip replacements and walk hunched over these days?🚨

It's as if #SARSCoV2 ages people by 30 to 40 years!

Why is it happening? 😔

#LongCOVID inhibits exercise, reduces ☀️, inhibits tissue repair, poor nutrition, and more.

#bone health
#medsky

French Nutrition Expert Targeted by Health Deepfakes Deepfake videos impersonating Serge Hercberg stayed online for days despite multiple reports, exposing gaps in platform moderation and risks to patient trust.

🇫🇷 #French Nutrition Expert Targeted by #Health #Deepfakes

www.medscape.com/viewarticle/...

#MedSky #AImedicine #AI #HealthAI #AIinHealthcare #MedTech

The Death of the Medical Fax Is Foretold — Again Medical offices are sick and tired of faxing, and federal officials agree. But modernization won’t be easy.

The Death of the #Medical #Fax Is Foretold — Again

www.medscape.com/viewarticle/...

#MedSky #AImedicine #AI #HealthAI #AIinHealthcare #MedTech

The JAK inhibitor #ruxolitinib was found to alleviate severe intractable diarrhea following treatment with cilta-cel in a small series of patients with #MultipleMyeloma #MMsm, offering clinical improvement to patients experiencing symptoms: https://ow.ly/u7Jc50YFG8g
#HemeSky #MedSky #myeloma