Midkine Attenuates Amyloid-β Fibril Assembly and Plaque Formation Proteomic profiling of Alzheimer’s disease (AD) brains has identified numerous understudied proteins, including midkine (MDK), that are highly upregulated and correlated with Aβ since the early disease stage, but their roles in disease progression ...

#Midkine (MDK) may help slow amyloid buildup in #Alzheimers disease. New findings show MDK reduces aggregation of Aβ40 and Aβ42 into fibrils, while loss of MDK increased plaque formation and microglial activation in AD mouse models.

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#Neuroscience #BetaAmyloid #RDStartsHere #rPeptide

A recent study shows that serum #Midkine suppresses #OsteoblastDifferentiation via the #PI3K-AKT pathway and increases #Inflammatory #Cytokines via the #NFκB pathway, promising a therapeutic target for postmenopausal #Osteoporosis. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Tiny Protein Confirmed to Dismantle the Toxic Clumps Linked to Alzheimer’s Disease Scientists at St. Jude Children’s Research Hospital have demonstrated for the first time that the protein midkine plays a preventative role in Alzheimer’s disease. Midkine is known to accumulate in Alzheimer’s patients, but rather than accelerate the disease, it seems to prevents a second, sticky protein from clumping together—the chief hallmark in this form of […] The post Tiny Protein Confirmed to Dismantle the Toxic Clumps Linked to Alzheimer’s Disease appeared first on Good News Network.

Tiny Protein Confirmed to Dismantle the Toxic Clumps Linked to Alzheimer’s Disease: Scientists at St. Jude Children’s Research Hospital have demonstrated for the first time that the protein midkine plays a preventative role in… @goodnewsnetwork.org #Alzheimers #Research #Science #Midkine #Health

This study reveals the growth factor Midkine (MDK) triggers a potent autocrine mechanism that deactivates NR2F1-dependent dormancy in DCCs, favoring metastatic outgrowth. This means MDK essentially "wakes up" dormant melanoma cells! #MIDKINE #NR2F1 #DDCs

So excited and proud to be a co-author on our new preprint: "Midkine inhibits dormancy of disseminated melanoma cells." Huge congrats to Carolina Rodriguez-Tirado & Maria Soledad Sosa for leading this fantastic work! 🎉 #MelanomaResearch #CancerDormancy #Midkine