Export or explode: export defects cause micronucleus membrane rupture. Hiba Baaziz and Daniela Cimini @virginiatech.bsky.social discuss recent work from Zych et al. (rupress.org/jcb/article/...), in Spotlight: rupress.org/jcb/article/...

#Micronuclei

Spotlight @jcb.org: Hiba Baaziz and Daniela Cimini @virginiatech.bsky.social discuss recent work from Zych et al. (rupress.org/jcb/article/...), showing that low RCC1 levels impair protein export in #micronuclei, causing overgrowth and rupture. rupress.org/jcb/article/...

Spotlight: Hiba Baaziz and Daniela Cimini @virginiatech.bsky.social discuss recent work from Zych et al. (rupress.org/jcb/article/...), showing that low RCC1 levels impair protein export in #micronuclei, causing overgrowth and rupture. rupress.org/jcb/article/...

RCC1 depletion drives protein transport defects and rupture in #micronuclei. New study from Molly G. Zych, Maya Contreras, Anna E. Mammel, and Emily M. Hatch @fredhutch.org: rupress.org/jcb/article/...

#disease #chromatin #epigenetics #cancer

In @jcb.org, Zych, Hatch et al. @fredhutch.org demonstrate that reduced RCC1 levels in #micronuclei impair protein export, causing persistent micronuclear growth, nuclear lamina gap expansion, and rupture. rupress.org/jcb/article/...

#disease #chromatin #epigenetics #cancer

Molly Zych, Emily Hatch et al. @fredhutch.org demonstrate that reduced RCC1 levels in #micronuclei impair protein export, causing persistent micronuclear growth, nuclear lamina gap expansion, and rupture. rupress.org/jcb/article/...

#disease #chromatin #epigenetics #cancer

📝 Online now - the Feature Review "Transactions on micronuclear DNA and implications for immune signaling" from @johnmaciejowski.bsky.social and Roger Greenberg.

#Micronuclei #NuclearEnvelope #EnvelopeRupture #DNAdamage #ImmuneResponse

Read it here: authors.elsevier.com/a/1m8Ps3S6Gf...

Very weird looking cell with a ring of yellow bundled microtubules surrounding a sort of hollow core with thick F-actin and long, buckled microtubules (MTs) emanating from under the nucleus, which is very lobular and misshapen. The ring of MTs contains lots of little micronuclei. There is a long, thin strand of DNA going from the nucleus out to the rim, in parallel with several of the spoke MTs.

Zooming in on the DNA strand running alongside the spoke-like microtubules from the fragmented nucleus to the thick bundled MT rim, where it is connected to a small micronuclear blob.

#MicroscopyMonday
This huge cell senescent survived 7d of paclitaxel, re-plating, & 4d more on plastic. Stained for #DNA (blue), #microtubules (yellow, red in zoom) and #F-actin (purple). Major #cytoskeleton weirdness.
Check out #DNA strand being pulled into the peripheral whorl of #micronuclei.

🧵 We are excited to share our new paper, showcasing micronuclAI, which leverages #AI and #ComputerVision to detect #chromosomal_instability #CIN #micronuclei

Congratulations to @miguelib.bsky.social and Lindsay Caprio for leading this project.

Health risks of rare earth elements exposure: Impact on mitochondrial DNA copy number and micronucleus frequency Toxic effects in terms of mitochondria and hereditary substances have been characterized in vitro for individual rare earth elements, while, the joint…

#gerontology #geriatrics #sustainability #micronuclei #ecology #SDGs #healthspan #NCDs

Increased
mitochondrial DNA copy number (MtDNACN),
peripheral blood lymphocyte micronucleus frequency.

Blood levels of rare earth elements
are associated with
DNA damage.
.
www.sciencedirect.com/science/arti...