Happy New Year! Feel free to join me on my challenge this year: no refined sugar or hfcs. I'm focusing on mitochondrial health instead:

www.youtube.com/watch?v=5dwc...

#mitohealth #HappyNewYear2026 #nosugarchallenge

Dual regulation of mitochondrial fusion by Parkin–PINK1 and OMA1 | Nature Mitochondrial stress pathways protect mitochondrial health from cellular insults1–8. However, their role under physiological conditions is largely unknown. Here, using 18 single, double and triple whole-body and tissue-specific knockout and mutant mice, along with systematic mitochondrial morphology analysis, untargeted metabolomics and RNA sequencing, we discovered that the synergy between two stress-responsive systems—the ubiquitin E3 ligase Parkin and the metalloprotease OMA1—safeguards mitochondrial structure and genome by mitochondrial fusion, mediated by the outer membrane GTPase MFN1 and the inner membrane GTPase OPA1. Whereas the individual loss of Parkin or OMA1 does not affect mitochondrial integrity, their combined loss results in small body size, low locomotor activity, premature death, mitochondrial abnormalities and innate immune responses. Thus, our data show that Parkin and OMA1 maintain a dual regulatory mechanism that controls mitochondrial fusion at the two membranes

Discover dual regulation of mitochondrial fusion by Parkin-PINK1 & OMA1 using 18 knockout/mutant mice. Explore mitochondrial stress roles! #MitoHealth PMID:39972141, Nature 2025, @Nature https://doi.org/10.1038/s41586-025-08590-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪