Maurizio Callari

@mauriziocallari.bsky.social

1 year ago

Here an overview of our #translational research on samples from the #NAPHER2 trial recently published in #NatComms @natureportfolio.nature.com. We identified #predictive #biomarkers and molecular dynamics in HER2+ER+ #breastcancer receiving chemo-free #targeted #treatment 👇

Maurizio Callari

@mauriziocallari.bsky.social

1 year ago

HER2+ER+ BC shows lower response to chemo+antiHER2 treatment. #Biomarker-guided alternative approaches could improve #outcomes and reduce #toxicities.
#NAPHER2 trial investigated #neoadjuvant #HER2 blockade and CDK4/6 inhibition with or without #endocrine therapy in HER2+ER+ BC.