Why do patients with cancer die? - Nature Reviews Cancer In this Roadmap, Boire et al. consider the immediate causes of mortality in patients with cancer, a topic not often considered in either preclinical or clinical research, and provide recommendations for how we can stimulate research to advance our mechanistic understanding of these causes with a....

FINALLY 🥁...our top most downloaded article of the year is…. 🥁🥁🥁

Why do patients with cancer die? By @tcox.bsky.social, Erik Sahai, et al.

https://bit.ly/3WIyl

#metastasis #cancertherapy #cancermodels

@crick.ac.uk @natureportfolio.bsky.social #NRCtop10of2024

Cancer therapy with antibodies - Nature Reviews Cancer In this Review, Paul et al. provide an overview of therapeutic antibodies as an important modality in cancer therapy today. They summarize the different approaches used by antibodies to target cancer cells including those of immune checkpoint inhibitors, bispecific antibodies...

🥳 Our 2nd most downloaded article in 2024:

Cancer therapy with antibodies by Paul, Gabelli, Ho, van Elsas et al.

https://bit.ly/3EjrG

#drugdevelopment #cancertherapy #antibodytherapy

@natureportfolio.bsky.social #NRCtop10of2024

A guide to artificial intelligence for cancer researchers - Nature Reviews Cancer This Review provides an introductory guide to artificial intelligence (AI)-based tools for non-computational cancer researchers. Here, Perez-Lopez et al. outline the general principles of AI for image analysis, natural language processing and drug discovery...

🥳 Our 3rd most downloaded article in 2024:

A guide to artificial intelligence for cancer researchers by @jnkt.bsky.social and colleagues

https://bit.ly/3yEzl

#AI #artificialintelligence #cancermodelling

@natureportfolio.bsky.social #NRCtop10of2024

Beyond genetics: driving cancer with the tumour microenvironment behind the wheel - Nature Reviews Cancer In their Review article, Fuchs and colleagues discuss how a single or a few mutations in adult cells can lead to invasive cancers without a high mutational burden, demonstrating that non-genetic factors induce the epigenetic changes necessary for tumorigenesis.

🥳 Our 4th most downloaded article in 2024:

Beyond genetics: driving cancer with the tumour microenvironment behind the wheel by @thefuchslab.bsky.social & colleagues

https://bit.ly/42Cvr

@rockefelleruniv.bsky.social @hhmi.bsky.social @natureportfolio.bsky.social #NRCtop10of2024

Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment - Nature Reviews Cancer In this Review, Polak, Zhang and Kuo discuss the currently available and rapidly evolving 3D tumour organoid models that capture the tumour immune microenvironment. They highlight opportunities for organoid-based investigations of tumour immunity, drug development and precision medicine.

🥳 Our 5th most downloaded article in 2024:

Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment by Calvin Kuo, Polk & Elisa Zhang

https://bit.ly/4jAOu

@stanfordpress.bsky.social @stanfordmedicine.bsky.social @natureportfolio.bsky.social #NRCtop10of2024

The evolutionary theory of cancer: challenges and potential solutions - Nature Reviews Cancer Clonal evolution is now a central theoretical framework in cancer research. In this Perspective, Laplane and Maley identify challenges to that theory such that some non-evolutionary phenomena in cancer cannot be captured by the theory.

🥳 Our 6th most downloaded article in 2024:

The evolutionary theory of cancer: challenges and potential solutions by @lucielaplane.bsky.social & @cmaley.bsky.social

https://bit.ly/3PWjS

#cancermodels #evolutionarybiology

@sorbonne-universite.fr @natureportfolio.bsky.social #NRCtop10of2024

Cancer drug-tolerant persister cells: from biological questions to clinical opportunities - Nature Reviews Cancer Resistance to therapy remains the biggest challenge to achieving cures in patients with cancer. In this Roadmap, Russo et al. overview the field of cancer drug-tolerant persister cells providing paths to advance our understanding of their biology with innovative technologies...

🥳 Our 7th most downloaded article in 2024:

Cancer drug-tolerant persister cells: from biological questions to clinical opportunities by Bardelli, Russo et. al
https://bit.ly/3CkSE

#persistercells #DTPs #cancerresistance

@natureportfolio.bsky.social #NRCtop10of2024

Exploiting temporal aspects of cancer immunotherapy - Nature Reviews Cancer The tumour immune microenvironment greatly affects responses to immune checkpoint therapies. In this Perspective, Zemek et al. explore the dynamic changes in response to both immunotherapy and conventional treatment and advocate for strategic combination therapies over time....

🥳 Our 8th most downloaded article in 2024:

Exploiting temporal aspects of cancer immunotherapy by Lesterhuis et al.
https://bit.ly/3Xs8l

#immunotherapy

@natureportfolio.bsky.social #NRCtop10of2024

Tertiary lymphoid structures in anticancer immunity - Nature Reviews Cancer Transient ectopic lymphoid structures known as tertiary lymphoid structures (TLS) have been observed in many solid tumour types. Teillaud et al. discuss how these TLS potentially orchestrate immune responses against tumours locally...

🥳 Our 9th most downloaded article in 2024:

Tertiary lymphoid structures in anticancer immunity by Dieu-Nosjean et al.
https://bit.ly/3WGcv

#cancermicroenvironment

@inserm.fr @natureportfolio.bsky.social #NRCtop10of2024

Emerging strategies to investigate the biology of early cancer - Nature Reviews Cancer Understanding the early steps of cancer development is crucial for cancer prevention. In this Review, the authors summarize the advantages and limitations of clinical samples, autochthonous mouse models and organoid models, alongside advanced techniques such as direct imaging, lineage tracing...

🥳 First up in #NRCtop10of2024:

Emerging strategies to investigate the biology of early cancer by Zhou, Tang & Wang
https://bit.ly/4hE1x

#cancerimaging #cancerscreening #cancerprevention

@natureportfolio.bsky.social #NRCtop10of2024

kermit the frog is standing in front of a red curtain with the words woooo !!! above him ALT: kermit the frog is standing in front of a red curtain with the words woooo !!! above him

Get ready... Starting Monday, we're counting down the top 10 most downloaded articles of 2024! 🎉 Don't miss it!

#NRCtop10of2024