LNPs that are potent in vitro but often not in vivo, therefore it is necessary to optimize in order to have a functional platform for drug delivery and clinical translation. Important! tiny changes in the lipid molecules of LNPs can result in a 1000-fold higher delivery! #NVGCT2025
Our second Keynote is Prof. Raimond Schiffelers from the University of Utrecht (@utrechtuniversity.bsky.social). He will delivered a talk on Optimizing Lipid Nanoparticles for Nucleic Acids Delivery. #NVGCT2025 #LNPs #nanoparticles
Next in line is a selected abstract by Peiyu Li from the #Amsterdamumc ( @amsterdamumc.bsky.social ) who will be presenting on the use of airway organoids to evaluate gene silencing in the patient context. #NVGCT2025
Next Session is on Cellular platforms and we start with Nicola Fattorelli from VIB-UAntwerpen, and he is talking about human microglia xenografts to model disease and develop cell therapies. #NVGCT2025
Last pitch comes from Tessa Prins (ExoVectory), Federico Cocozza (Utrecht University) and Despoina Trasanidou (Sanquin) who combine their expertise and passion into one project. The final winner will be announced at the end of the meeting! Congratulations to all the participants!! #NVGCT2025 #ZonMw
The next speaker is Karin Pike-Overzet from #LUMC who will be talking about a clinical trial for RAG1-SCID patients using hematopoietic stem-cell therapy combined with lentiviral therapy. #SCID #NVGCT2025 #clinicaltrial #RAG1
The next speaker is selected from the submitted abstracts and is Deja Porenta who is working on assessing the Cas9-directed immune response in mice at the @utrechtuniversity.bsky.social #NVGCT2025 #LNPs #Cas9 #nanoparticles
The next session is on Genetic Technologies, and the first speaker is Prof. Sabine Fuchs (from @umcutrecht.bsky.social). She will talk about prime editing for inherited metabolic diseases. #NVGCT2025 #metabolicdiseases #primeediting #liver
To end, he give the look to the future. Once again, congratulations to Prof. Vincenzo Cerullo for receiving this NVGCT award for his contribution to the field! #NVGCT2025 #award #oncolyticvirus #peptides #cancer
However, before starting his presentations he had a clear message to the quizzmasters of the famous NVGCT pubquiz "Ricotta is a fantastic cheese but is not included in Lasagna or Pasta Alfredo" Statement from an Italian-dominated team #NVGCT2025
This year the the NVGCT Outstanding Award is awarded to Prof. Vincenzo Cerullo, who has been working on precision cancer oncolytic immunotherapy and will provide a presentation "Dressing up viruses to fool cancer: fast pipeline for personalized cancer vaccines" #NVGCT2025 #award #oncolyticvirus
The last presentation of this session and today is given by Olivier de Jong (@utrechtuniversity.bsky.social) on delivery and release strategies for CRISPR/Cas9 system using extracellular vesicles #EVs #NVGCT2025 #CRISPR
The next session on delivery started with the invited lecture of Roy van der Meel (@tue.nl) to talk on nanotechnology for delivery of RNA, small molecules, protein to immune cells by systemic delivery using #LNPs #NVGCT2025
the last speaker of this session is Martina Paladino from @utrechtuniversity.bsky.social and she will explain her postdoc project on the lipid nanoparticles delivery to induce dopaminergic neurons both in vitro and in vivo #NVGCT2025 #LNPs #nanoparticles #neurons
Thus, personalized approaches like n-of-1 approaches at academic level might be the future. #NVGCT2025 #DCRT @dutchantisense.bsky.social @oligogirl.bsky.social
This approach could be also used in adults, but probably the neurogenesis part will be less effective in adults #NVGCT2025
Good news is that a clinical trial phase II has been granted!
We had the honor to have Cees Smit who presented his book "Gene and Cell Therapies in Europe". This book describes the breakthroughs in ATMPs, offering real prospects of cures. #NVGCT2025
@revvity.bsky.social @miltenyibiotec.bsky.social
Once again, thank you very much for your support and hope you enjoy the experience at #NVGCT2025 #sponsor #sponsorpitch
To finish the #DARE-NL session, Trudy Straetemans is back on stage to present how DARE-NL can help us preparing and accelerating a first in-human clinical study. #NVGCT2025
Next, Harry Dolstra (from @radboudumc.bsky.social) is presenting the work of his group on developing #CAR-NK for clinical application. Using umbilical cord stem cells they can develop NK cells in 35 days in a GMP-compliant scalable manufacturing process. #NVGCT2025
Edwin Bremer (from @rug.nl) presented how to develop a lentiviral manufacturing platform at academic level in the Netherlands, to provide therapies at the lowest price possible. For that they are developing a GMP-compliant freedom-to-operate manufacturing process. #NVGCT2025
The NVGCT Annual Meeting 2025 kicks off with a session organized by DARE-NL in which we will learn on how to accelerate clinical testing of novel ATMPs to ensure timely and sustainable access.Trudy Straetemans (@umcutrecht.bsky.social) provided an introduction to #DARE-NL #NVGCT2025
