Opposite effects on #NeointimaFormation in #SmoothMuscleCell #InsulinReceptor vs #IGF1R KO🐭

IGF1R KO➡️
⏫InsR homodimer🧐➡️
⏫insulin sensitivity of SMC➡️
⏫SMC proliferation

InsR KO⏬IGF1R signaling in SMCs

Fig 1F is the same as Fig 2F...😼
George King lab #NatureComms 2019
www.nature.com/articles/s41...