紫外線から肌を守るために知っておきたいDNA修復の秘密 ポーラ化成工業の研究成果に基づき、UVから肌を守るためのDNA修復の重要性と、IGF1Rの役割を解説します。

紫外線から肌を守るために知っておきたいDNA修復の秘密 #ポーラ化成工業 #IGF1R #アルニカエキス

ポーラ化成工業の研究成果に基づき、UVから肌を守るためのDNA修復の重要性と、IGF1Rの役割を解説します。

IGF-1R Antibody Reduces Thyroid Eye Disease Signs, Improves Quality of Life - Ophthalmology Advisor Researchers assessed the quality of life measures of patients with thyroid eye disease treated with Veligrotug, a full antagonist humanized mAb to IGF-1R.

#AAO2025: Treatment with an intravenously delivered, anti-insulin-like growth factor-1 receptor (IGF-1R) antibody can reduce signs of thyroid eye disease (#TED) and improve quality of life.

Read here: https://bit.ly/3LrozWR

#Ophthalmology #IGF1R #ThyroidEyeDisease

Amgen’s Tepezza granted marketing authorisation in the UK - PharmaTimes Teprotumumab approved as first targeted treatment for thyroid eye disease

#thyroideyedisease #TED #Amgen #Tepezza #Teprotumumab #Gravesophthalmopath #GravesEyeDisease #autoimmunedisorder #overactivethyroid #marketingauthorisation #MHRA #immunotherapy #insulinlikegrowthfactor1receptor #IGF1R #phase3OPTICtrial #OPTICtrial #proptosis
pharmatimes.com/news/amgens-...

Opposite effects on #NeointimaFormation in #SmoothMuscleCell #InsulinReceptor vs #IGF1R KO🐭

IGF1R KO➡️
⏫InsR homodimer🧐➡️
⏫insulin sensitivity of SMC➡️
⏫SMC proliferation

InsR KO⏬IGF1R signaling in SMCs

Fig 1F is the same as Fig 2F...😼
George King lab #NatureComms 2019
www.nature.com/articles/s41...