Proud collaboration with the Baker Lab (UW) and Bai Lab (UTSW).
#ProteinDesign #InsulinReceptor #MolecularCell #BiasedAgonism #TranslationalScience

#DiabeticBladderDysfunction

#SmoothMuscleCell #InsulinReceptor KO🐭
⏬Body weight, ⏬#GlucoseTolerance & ⏫#InsulinResistance

Dysregulated Urodynamics

Thinned Bladder SM layer▶️InsR KO dampens BOTH proliferation & contractility of bladder SMC🤠

Diabetes 2022
diabetesjournals.org/diabetes/art...

Opposite effects on #NeointimaFormation in #SmoothMuscleCell #InsulinReceptor vs #IGF1R KO🐭

IGF1R KO➡️
⏫InsR homodimer🧐➡️
⏫insulin sensitivity of SMC➡️
⏫SMC proliferation

InsR KO⏬IGF1R signaling in SMCs

Fig 1F is the same as Fig 2F...😼
George King lab #NatureComms 2019
www.nature.com/articles/s41...