Nephron progenitor fate is modulated by angiotensin type 1 receptor signaling in human kidney organoids Abstract. The renin-angiotensin system (RAS) is essential for normal kidney development. Dysregulation of the RAS during embryogenesis can result in kidney

Dr. Justin Chun's team from @ucalgarymed.bsky.social
identified a role for AT1R signaling in regulating nephron progenitor fate during #nephrogenesis in kidney #organoids.

@StemCellsJournl | 🔗 bit.ly/4iZiwVb

Post from @OrganoidNews on Twitter

My continued biomedical education

Principles of human & mouse nephron development #Nephrogenesis

"each fold, bend and twist taken during nephrogenesis might serve a function in the development of the mature nephron"🤓

#NatRevNeph 2022
www.nature.com/articles/s41...

FoxD1+ stromal progenitor Netrin 1 controls #Nephrogenesis & Arterial #BranchingMorphogenesis in developing kidney😍

Not phenocopied by Unc5c/Ntn3 KO

Arterial morpho-defects diminish in adult🐭, but +#VascularPermeability

Lori O'Brien lab Development 2023
journals.biologists.com/dev/article/...