1/ The differential diagnosis of acute renal failure in patients with multiple myeloma includes light chain cast nephropathy, amyloidosis, and monoclonal immunoglobulin deposition disease, among other possibilities.
#TeachingPoints #kidneypath #renal #pathsky #nephropath
Microphotograph showing a glomerulus with fine granular positivity along the glomerular basement membrane (NELL1 immunohistochemistry staining, 400×). NELL1, neural epidermal growth factor-like protein 1.
Another NELL1 and membranous, but not mercury this time
journals.lww.com/kidney360/fu... in @asnpublications.bsky.social K360
#NephSky #NephroPath
(1/2) The image shows lymphocytic tubulitis and surrounding lymphocytic inflammation. These findings are most commonly seen in acute T-cell mediated rejection (Banff IA or IB). #nephropath #renalpath
The image shown comes from a kidney transplant patient with a rise in serum creatinine. What is the most likely diagnosis and what immunohistochemical stain would you want to rule out a less common disease sometimes seen in kidney transplants?
#DiagnoseThis #renalpath #nephropath
A limited sample showed this lesion and negative staining on paraffin-retrieved IF tissue. What is your diagnosis?
#DiagnoseThis #renalpath #nephropath
The photo shows a fibrocellular crescent dissecting through the center of a glomerulus. In the peripheral portions of the glomerulus no obvious endocapillary proliferation is present, but the glomerulus is so disrupted that this evaluation is made difficult.
#nephropath #renalpath
What is your diagnosis? What would you want to confirm for your diagnosis?
#DiagnoseThis #renalpath #nephropath
The H&E photomicrograph shows intratubular, lightly pigmented casts with a granular to focally beaded morphology and is suspicious for myoglobin cast nephropathy.
#nephropath #renalpath
What is your diagnosis? What additional stains would you like to confirm your diagnosis?
#DiagnoseThis #renalpath #nephropath
(1/5) The photomicrograph shows PAS negative intratubular casts that are focally broken and have a mild cellular reaction. While these casts are not a ‘textbook’ example, they are compatible with...
#nephropath #renalpath
The electron photomicrograph shows diffuse epithelial foot process effacement with microvillus transformation in the absence of definitive immune complex deposits and suggests a podocytopathy.
#nephropath #renalpath
What class of disease does this patient have and how did they present clinically?
#DiagnoseThis #renalpath #nephropath
These findings are indicative of intravascular hemolysis with hemoglobinuria. Immunohistochemical staining for hemoglobin and myoglobin is of utmost importance, given that the morphologic features of these two forms of cast nephropathy are indistinguishable. (4/4)
#renalpath #nephropath
Some of the newest additions to the #NephSky starter pack!
We are 132 - go.bsky.app/H4td28C
There’s also a separate #PedNeph Started pack from @kidneywiki.bsky.social
Do we need a #NephroPath starter pack @changucanspare.bsky.social ? Maybe shortly as people start to join!
It is such a treat to learn, re learn, re re learn and repeat from the pathologist who has such an infectious vibe.
@nephrosharma
@arkanalabs
@KIDNEYcon
#Nephtwitter
#Nephropath
are our fellows getting enough #nephropath education?
@ldcornell @VBijol @ChangUCanSpare @kireports www.kireports.org/article/S2468-0249(17)30...
Vanesa Bijol and many others @AJKDonline https://www.ncbi.nlm.nih.gov/pubmed/29866458 Congophilic Fibrillary Glomerulonephritis: A Case Series. #nephropath
Cool slice of a glomerulus on biopsy showing the proximal tubule. #nephropath https://www.instagram.com/p/BN2AL5sj3NL/
