We’re excited for The Changing Brain conference next week, sponsored by CNCM @ucirvine.bsky.social, @cajalclub.bsky.social & @alleninstitute.org. There’s a packed speaker lineup — what’s your “can’t miss” talk? cncm.som.uci.edu/2025-cncm-co...
#neuroskyence #neuralcircuitry #changingbrain

AXON2025 Meeting Rotterdam Topics Synaptic plasticity Local translation Neuron-glia interactions Brain development and evolution Human models Single cell profiling Advanced imaging technology And more!

Busy September 17-19? You should be! Join us at #AXON2025 to share research on #synapticplasticity, #braindevelopment, #neuralcircuitry, and more. Early bird registration ends May 1 🦤

#neuroscience #neuroskyence #axonguidance

Three systems of circuit formation: assembly, updating and tuning | Nature Reviews Neuroscience Understanding the relationship between genotype and neuronal circuit phenotype necessitates an integrated view of genetics, development, plasticity and learning. Challenging the prevailing notion that emphasizes learning and plasticity as primary drivers of circuit assembly, in this Perspective, we delineate a tripartite framework to clarify the respective roles that learning and plasticity might have in this process. In the first part of the framework, which we term System One, neural circuits are established purely through genetically driven algorithms, in which spike timing-dependent plasticity serves no instructive role. We propose that these circuits equip the animal with sufficient skill and knowledge to successfully engage the world. Next, System Two is governed by rare but critical ‘single-shot learning’ events, which occur in response to survival situations and prompt rapid synaptic reconfiguration. Such events serve as crucial updates to the existing hardwired knowledge base

Discover how genes, development, plasticity, and learning form circuits. Unpack the 3 systems: assembly, updating, tuning. #NeuralCircuitry PMID:39994473, Nat Rev Neurosci 2025, @NatRevNeurosci @Harvard https://doi.org/10.1038/s41583-025-00910-9 #Medsky #Pharmsky 🧪