#Population #immunity to clade 2.3.4.4b #H5N1 is dominated by anti - #neuraminidase #antibodies

#Population #immunity to clade 2.3.4.4b #H5N1 is dominated by anti - #neuraminidase #antibodies, etidiohnew.blogspot.com/2026/04/popu...

#Oseltamivir aziridines are potent #influenza #neuraminidase #inhibitors and imaging agents

#Oseltamivir aziridines are potent #influenza #neuraminidase #inhibitors and imaging agents, etidiohnew.blogspot.com/2026/03/osel...

#Immunity to #hemagglutinin and #neuraminidase results in additive reductions in #airborne #transmission of #influenza #H1N1 virus in #ferrets

#Immunity to #hemagglutinin and #neuraminidase results in additive reductions in #airborne #transmission of #influenza #H1N1 virus in #ferrets, etidiohnew.blogspot.com/2026/03/immu...

A newly emergent N1 #neuraminidase associated with clade 2.3.4.4b highly pathogenic avian #influenza #H5 viruses in North #America

A newly emergent N1 #neuraminidase associated with clade 2.3.4.4b highly pathogenic avian #influenza #H5 viruses in North #America, etidiohnew.blogspot.com/2026/03/a-ne...

Amino acid #mutations K54E and S154P in the #neuraminidase attenuate #H3N2 #canine #influenza virus in mice

Amino acid #mutations K54E and S154P in the #neuraminidase attenuate #H3N2 #canine #influenza virus in mice, etidiohnew.blogspot.com/2026/02/amin...

In a recent study published in Glycoscience & Therapy, a team of researchers confirmed that neuraminidase 1is significantly elevated in lipopolysaccharide-induced ALI and is a key factor driving the endothelial disfunction. Learn more: https://ow.ly/UMAu50XQAMR
#Neuraminidase #lung injury #Baicalin

Engineered nanobodies improved respiratory defenses in preclinical study In a multi-institutional study published today in Nature Nanotechnology, researchers from The University of Texas MD Anderson Cancer Center reported that engineered bispecific nanobodies successfully…

Engineered #nanobodies improved respiratory defenses ...

| #viruses | #infections | #influenza | #neuraminidase | Via eurekalert .org

Intra-patient #neuraminidase #mutations in avian #H5N1 #influenza virus reduce #sialidase activity to complement weaker hemagglutinin binding and facilitate #human infection

Intra-patient #neuraminidase #mutations in avian #H5N1 #influenza virus reduce #sialidase activity to complement weaker hemagglutinin binding and facilitate #human infection, etidiohnew.blogspot.com/2026/01/intr...

#Evolution of #antibody cross-reactivity to #influenza #H5N1 #neuraminidase from an N2-specific germline

#Evolution of #antibody cross-reactivity to #influenza #H5N1 #neuraminidase from an N2-specific germline, etidiohnew.blogspot.com/2025/11/evol...

#Evolution of #antibody cross-reactivity to #influenza #H5N1 #neuraminidase from an N2-specific germline

#Evolution of #antibody cross-reactivity to #influenza #H5N1 #neuraminidase from an N2-specific germline, etidiohnew.blogspot.com/2025/10/evol...

Cross-reactive #neuraminidase inhibition #antibodies against #H5N1 by consecutive #influenza A imprinting cohorts of the past century: population-based serosurvey, British Columbia, #Canada

Cross-reactive #neuraminidase inhibition #antibodies against #H5N1 by consecutive #influenza A imprinting cohorts of the past century: population-based serosurvey, British Columbia, #Canada, etidiohnew.blogspot.com/2025/09/cros...

Cross-reactive #human #antibody responses to #H5N1 #influenza virus #neuraminidase are shaped by immune history Media Monitoring for Signals about Emerging Threats

Cross-reactive #human #antibody responses to #H5N1 #influenza virus #neuraminidase are shaped by immune history, etidiohnew.blogspot.com/2025/09/cros...

Broad Neuraminidase Antibodies Confer Protection Against Seasonal and Avian Influenza Viruses  Neuraminidase (NA) is a critical target for universal influenza vaccines and therapeutic antibodies, yet its antigenic landscape remains incompletely understood. Here we identify two broadly cross-protective monoclonal antibodies, CAV-F6 and CAV-F34, from influenza-infected individuals. These antibodies inhibit NA enzymatic activity across multiple subtypes and confer protection against seasonal influenza in female mouse models. Importantly, the two antibodies also neutralize emerging avian strains, including recent bovine H5N1 and H7N9 strains, both with pandemic potential. Structural studies reveal that both antibodies target conserved regions of the NA active site via HCDR3, blocking sialic acid interaction.   Furthermore, we observe distinct occupancy for the two antibodies on N2 tetramer, which is likely due to differences in binding affinity. Our findings provide molecular insights into NA-targeted immunity and offer a foundation for developing broadly protective influenza vaccines and therapeutics. Influenza A virus neuraminidase (NA) is an important target for universal influenza vaccines. Here, the authors identify two monoclonal antibodies, CAV-F6 and CAV-F34, that inhibit NA activity across multiple subtypes, offering protection against seasonal and emerging avian influenza strains, thus advancing the development of broadly protective vaccines and therapeutics.   Published in Nat. Comm. (Aug. 2, 2025): https://doi.org/10.1038/s41467-025-62040-1 

Further evidence on the important role played by neuraminidase (NA) antibodies and its possible role as therapeutic and prophylactic agents. #H5N1 #birdflu #influenza #neuraminidase - Nature Communications

#Neuraminidase #imprinting and the age-related #risk of zoonotic #influenza

#Neuraminidase #imprinting and the age-related #risk of zoonotic #influenza, etidiohnew.blogspot.com/2025/07/neur...

A 15-year study of #neuraminidase #mutations and the increasing of S247N mutation in #Spain

A 15-year study of #neuraminidase #mutations and the increasing of S247N mutation in #Spain, etidiohnew.blogspot.com/2025/07/a-15...

#Evolution of #antibody cross-reactivity to #influenza #H5N1 #neuraminidase from an N2-specific germline

#Evolution of #antibody cross-reactivity to #influenza #H5N1 #neuraminidase from an N2-specific germline, etidiohnew.blogspot.com/2025/06/evol...

#Global #update on susceptibilities of #influenza viruses to #neuraminidase #inhibitors and the cap-dependent endonuclease inhibitor #baloxavir, 2020–2023

#Global #update on susceptibilities of #influenza viruses to #neuraminidase #inhibitors and the cap-dependent endonuclease inhibitor #baloxavir, 2020–2023, etidiohnew.blogspot.com/2025/06/glob...

Kinetic MUNANA assay reveals functionally relevant antibody epitopes on Influenza A virus neuraminidase - npj Viruses npj Viruses - Kinetic MUNANA assay reveals functionally relevant antibody epitopes on Influenza A virus neuraminidase

Very proud of Danica Besavilla, PhD student in the lab, receiving the Poster award at the #Antibodies & Complement meeting, taking place in Catania.
She presented her paper on mAbs to #Influenza #Neuraminidase , just published in @natureportfolio.nature.com #npjViruses
www.nature.com/articles/s44...

5/8 Genetic archaeology reveals D1.1's Frankenstein origins: four segments mixing Eurasian and North American lineages. Its unique neuraminidase segment appeared for the first time in this British Columbia clade, possibly increasing viral shedding.
#GeneticOrigins #Neuraminidase #ViralShedding

#Phylogenetic Analysis and Spread of HPAI #H5N1 in Middle Eastern Countries Based on #Hemagglutinin and #Neuraminidase Gene Sequences

#Phylogenetic Analysis and Spread of HPAI #H5N1 in Middle Eastern Countries Based on #Hemagglutinin and #Neuraminidase Gene Sequences, etidiohnew.blogspot.com/2025/05/phyl...

Universal Flu Vaccine May No Longer Be a Long Shot For decades, researchers have sought out strategies to circumvent the rapid incessant evolution of flu strains. A new approach holds promise.

#UniversalFluVaccine 💉May No Longer Be a Long Shot, #antibodies target both head & stalk of the most abundant surface protein on the #influenza virus, #Hemagglutinin with 5–10 times more than #neuraminidase & targeting regions NOT mutating.
genengnews.com/topics/genom...