https://www.cell.com/cell/fulltext/S0092-8674%2825%2900502-1

#NeuroImmunologyPower! Yang, Li, &co show @cp-cell.bsky.social that the serotonin transporter depletes intratumoral level of serotonin dampening CD8 T cell antitumor immunity. Using an antidepressive that blocks the transporter reduces tumor growth & potentiates PD1 blockade therapy! t.co/NRhBZiFLIc

A neuroimmune pathway drives bacterial infection Dysregulation of the dopamine-ACOD1 axis correlates with sepsis severity.

#WeekendRead #NeuroimmunologyPower #ImmunometabolismPower #NotOnlyItaconate! Kang &co show Science Advances that #dopamine inhibits ACOD1 upregulation by TLR4/CREB1, preventing ACOD1 (not itaconate) dependent PDL1 induction, protecting against inflammation-induced #immunosuppression during #sepsis!

B cells modulate lung antiviral inflammatory responses via the neurotransmitter acetylcholine - Nature Immunology Cembellin-Prieto and colleagues find that B cells in the lung are capable of producing acetylcholine and that these regulate early macrophage activation and control influenza virus replication.

#WeekendRead! #NeuroImmunologyPower! Baumgarth lab &co show @natimmunol.baky.social that lung B cells produce acetylcholine for interstitial macrophages dampening TNF during influenza virus infection, thus favoring late repair at the cost of initial virus growth!
www.nature.com/articles/s41...

Macrophages protect against sensory axon loss in peripheral neuropathy - Nature A study in a mouse model of obesity and prediabetes demonstrates that recruitment of macrophages to nerves has a protective role in diet-induced peripheral neuropathy.

#NeuroImmunologyPower! Woolf &co show @nature.com that peripheral neuropathy associated with type 2 #diabetes is delayed by recruitment of galactin-3 producing #macrophages which delay terminal sensory axon degeneration! #ScienceSavesLives www.nature.com/articles/s41...