A neuroimmune pathway drives bacterial infection Dysregulation of the dopamine-ACOD1 axis correlates with sepsis severity.

#WeekendRead #NeuroimmunologyPower #ImmunometabolismPower #NotOnlyItaconate! Kang &co show Science Advances that #dopamine inhibits ACOD1 upregulation by TLR4/CREB1, preventing ACOD1 (not itaconate) dependent PDL1 induction, protecting against inflammation-induced #immunosuppression during #sepsis!