Microglial reactivity and neuroinflammation-driven changes in motivational behaviors are regulated by Orai1 calcium channels The Ca2+ channel Orai1 in microglia links systemic inflammation to depressive-like behaviors in mice.

How does #neuroinflammation trigger depressive-like behaviors?

Researchers in #ScienceSignaling show that #Orai1 sustains production of proinflammatory cytokines from microglia and that Orai1-deficient mice display less pronounced depressive-like behaviors. https://scim.ag/4rmJSZQ