Scientists identify GPR133/ADGRD1 as a regulator of #osteoblast function & bone formation, where activation with AP503 alleviates osteoporosis in mice, positioning it as a therapeutic target for #osteoporosis. @unileipzig.bsky.social

#STTT #OpenAccess: doi.org/10.1038/s413...

Published in Genes & Diseases on January 12, 2024, the recent study led by researchers cuticle homolog 2 (NKD2) as a critical regulator of bone cell differentiation.
#Osteoblast #Wnt/β-catenin
Details: doi.org/10.1016/j.gendis.2024.101209

Decreasing miR-433-3p Activity in the Osteoblast Lineage Blunts Glucocorticoid-mediated Bone Loss Abstract. Glucocorticoid excess causes bone loss due to decreased bone formation and increased bone resorption; miR-433-3p is a microRNA (miRNA) that negat

Decreasing mir-433-3p activity in the #osteoblast lineage blunts glucocorticoid-mediated #bone loss. Featured study in #Endocrinology #FreeToView
@endocrinesociety.bsky.social
doi.org/10.1210/endo...

One can isolate #ExtracellularVesicle from🐭Bone (tibia/femur, not bone marrow)!?😮

Isolated EVs from cultured #SmoothMuscleCell or #Osteoblast (MC3T3 differentiated)⏫ lesion #Calcification (w/o impacting lesion burden) in hyperlipidemic🐭

Matrix Biol 2024
www.sciencedirect.com/science/arti...

Lyme disease reduces bone volume, possibly by reducing osteoblast numbers #Lymedisease #osteoblast #osteopenia iai.asm.org/content/early/2016/12/08...

Lyme disease reduces bone volume, possibly by reducing osteoblast numbers #Lymedisease #osteoblast #osteopenia http://ow.ly/GWl3307MP7A

Lyme disease reduces bone volume, possibly by reducing osteoblast numbers #Lymedisease #osteoblast #osteopenia http://ow.ly/xnKM307otry

Lyme disease reduces bone volume, possibly by reducing osteoblast numbers #Lymedisease #osteoblast #osteopenia http://ow.ly/9o7J307otnM