Effects of partial versus complete aortic... : Journal of Trauma and Acute Care Surgery INTRODUCTIONREBOA is a recognized rescue strategy in exsanguinating shock. Nevertheless, effects of partial- versus total-REBOA inflation on both...

Partial REBOA looks like a gentler way to buy time in hemorrhagic shock.

In pigs, partial occlusion preserved mesenteric flow and jejunal microcirculation vs total REBOA, with better pH/lactate trends. Tracked continuously with #OxyFlo Pro laser Doppler (jejunal mucosa + serosa).
#REBOA #Trauma

Effects of perioperative dexmedetomidine on renal vascular function and renovascular histopathology in ovine cardiopulmonary bypass - Intensive Care Medicine Experimental Background Cardiopulmonary bypass (CPB) is integral to the conduct of cardiac surgery but is associated with postoperative acute kidney injury (AKI). Dexmedetomidine, an α₂-adrenoceptor agonist with a...

What if renal perfusion looks “normal” on CPB, but the microvasculature is primed to constrict?

Ovine CPB study: dexmedetomidine ↑ α1 vasoconstrictor sensitivity (2.3×), while cortex/medulla perfusion + pO₂ ( #OxyFlo & #OxyLite) showed no group differences.

#AKI #CPB

Chronic hypoxia impairs L‐type Ca2+ channel‐mediated myogenic vasoconstriction and cerebral autoregulation in newborn lambs Abstract figure legend Cerebral autoregulation in control 1-week-old newborn lambs was found to be intact in response to both rapid (45 s) and slow (∼1 h) excursions in arterial blood pressure, demon....

What if a week of "mild" hypoxia is enough to make neonatal brain blood flow pressure-passive?

J Physiol lamb data shows hypoxia blunts L-type Ca²⁺-dependent autoregulation, revealed with #OxyFlo cerebral flow monitoring.

physoc.onlinelibrary.wiley.com/doi/10.1113/...

#Neonatology #Hypoxia #Blood

Short new video 👉 intro to #OxyFlo, our laser-Doppler tissue blood flow monitor for continuous, real-time microvascular perfusion measurements in vivo.

Watch the clip, then reach out if you’d like details or pricing for your model.

#WoundHeling #Microcirculation #PreclinicalResearch #Stroke

Regional venous-to-arterial carbon dioxide pressure and content differences during endotoxemic shock: influence of hydrogen ion accumulation vs. Haldane effect - Intensive Care Medicine Experimental Background The relationship between carbon dioxide pressures (PCO2) and contents (CCO2) is linked to the Haldane effect. Nevertheless, under shock conditions, hydrogen ion accumulation might strongly ...

What if ΔPCO₂ in shock is more about acidosis than Haldane effect?
New study shows hydrogen ions dominate the CO₂ gap while flow recovers. #OxyFlo measured jejunal microvascular flow to link perfusion with CO₂ dynamics.
#Shock #CriticalCare #CO2 #LDF #Physiology

link.springer.com/article/10.1...

Effects of tempol on renal medullary tissue hypoxia in an ovine model of Gram‐negative septic acute kidney injury Renal arterial infusion of tempol (RAT) at the onset of Gram-negative sepsis can prevent sepsis-induced medullary tissue hypoxia and acute kidney injury (AKI). However, it is not known whether treatm....

What if the clock is the biggest variable in septic #AKI?
In an ovine model, tempol begun at 24–31 h did not reverse medullary hypoxia; normalization followed antibiotics.
#OxyLite (pO2) & #OxyFlo (perfusion) revealed cortex-vs-medulla differences in real time.

#Sepsis #TranslationalResearch

Effect of flow change on brain injury during an experimental model of differential hypoxaemia in cardiogenic shock supported by extracorporeal membrane oxygenation - Scientific Reports Scientific Reports - Effect of flow change on brain injury during an experimental model of differential hypoxaemia in cardiogenic shock supported by extracorporeal membrane oxygenation

What if a simple flow change could curb ECMO-related brain injury?
In an ovine VA-ECMO DH model, increasing flow to 4.5 L/min boosted PbTO₂ (+215%) and reduced histologic damage vs 2.5 L/min.
Cerebral measurements achieved with #OxyLite (pO₂) + #OxyFlo (laser-Doppler flow).
#ECMO #Neuroprotection