Physiological and morphological development of the spermatheca in queens of the ant Crematogaster osakensis (Hymenoptera: Formicidae: Myrmicinae) The spermatheca is a specialized organ for sperm storage and is essential for reproductive success, particularly in ants, where queens preserve the vi…

pO₂ monitoring in insects is not something we see every day, which is why we loved this paper.
Ant queens build near-anoxic spermatheca early (key for long-term sperm storage), while body oxygen shifts around the nuptial flight. #OxyLite + NX-BF/O/E helped measure internal pO₂.

#InsectPhysiology

Effects of perioperative dexmedetomidine on renal vascular function and renovascular histopathology in ovine cardiopulmonary bypass - Intensive Care Medicine Experimental Background Cardiopulmonary bypass (CPB) is integral to the conduct of cardiac surgery but is associated with postoperative acute kidney injury (AKI). Dexmedetomidine, an α₂-adrenoceptor agonist with a...

What if renal perfusion looks “normal” on CPB, but the microvasculature is primed to constrict?

Ovine CPB study: dexmedetomidine ↑ α1 vasoconstrictor sensitivity (2.3×), while cortex/medulla perfusion + pO₂ ( #OxyFlo & #OxyLite) showed no group differences.

#AKI #CPB

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Deep-tissue oxygenation with a PLD array: 4.26 cm phantoms, accurate renal maps to 3.85 cm in vivo, validated by an #OxyLite kidney sensor placement.

Read here: opg.optica.org/boe/fulltext...

#Photoacoustics #TissueOxygenation

Challenges in functional hydrogel application for chronic tympanic membrane perforation: practical limitations and lessons learned - Biomedical Engineering Letters Chronic tympanic membrane (TM) perforations often persist due to oxidative stress and hypoxia in the middle ear. A minimally invasive, biocompatible hydrogel addressing these challenges could serve as...

What if hydration is a key variable in chronic eardrum repair?

Biomed Eng Lett: Mn-porphyrin hydrogel scavenged ROS and generated O₂ in vitro (validated with #OxyLite, Fig. 2d) but showed no healing in rats, likely due to gel dehydration and collapse in the middle ear.

#Biomaterials #WoundHealing

In Vitro Dissolved Oxygen Monitoring in Hypoxia Chambers Explore how an in vitro system that can be utilized within hypoxic chambers ensures precise dissolved oxygen control in cell cultures and media. Hypoxia chambers are used worldwide by research investi...

Stop guessing pericellular oxygen and just measure it.

Guide to dissolved O2 in hypoxia chambers: think in mmHg, verify in media pO2, track stability with #OxyLite and #HypoxyLab.

Read here: www.oxford-optronix.com/resources/in...

#pO2 #Hypoxia #ResearchTools

What if oxygen is the switch for FLASH at the molecular scale?
At 5% O₂, UHDR yields fewer DNA strand breaks than LDR & at ~21% O₂ that advantage vanishes. #HypoxyLab set ~40 mmHg O₂ and #OxyLite confirmed O₂ and sealing to keep conditions true.

Read here👉 arxiv.org/pdf/2510.15478

Rapidly dissolving polymeric microbubbles promote supersaturation and in-situ formation of acoustic nanobubbles capable of dynamic pressure sensing Developing noninvasive methods for monitoring intravascular and intracardiac pressures is crucial for advancing the diagnosis and management of cardio…

Novel paper by a @harvard.edu team used nanobubbles to convert pressure into an ultrasound signal, and our #OxyLite tied mechanism to outcome by tracking dissolved oxygen in real time.
The technique may open safer, more sensitive #cardiology pressure monitoring.

#BiomedicalEngineering #Nanobubbles

Effects of tempol on renal medullary tissue hypoxia in an ovine model of Gram‐negative septic acute kidney injury Renal arterial infusion of tempol (RAT) at the onset of Gram-negative sepsis can prevent sepsis-induced medullary tissue hypoxia and acute kidney injury (AKI). However, it is not known whether treatm....

What if the clock is the biggest variable in septic #AKI?
In an ovine model, tempol begun at 24–31 h did not reverse medullary hypoxia; normalization followed antibiotics.
#OxyLite (pO2) & #OxyFlo (perfusion) revealed cortex-vs-medulla differences in real time.

#Sepsis #TranslationalResearch

Effect of flow change on brain injury during an experimental model of differential hypoxaemia in cardiogenic shock supported by extracorporeal membrane oxygenation - Scientific Reports Scientific Reports - Effect of flow change on brain injury during an experimental model of differential hypoxaemia in cardiogenic shock supported by extracorporeal membrane oxygenation

What if a simple flow change could curb ECMO-related brain injury?
In an ovine VA-ECMO DH model, increasing flow to 4.5 L/min boosted PbTO₂ (+215%) and reduced histologic damage vs 2.5 L/min.
Cerebral measurements achieved with #OxyLite (pO₂) + #OxyFlo (laser-Doppler flow).
#ECMO #Neuroprotection

Frontiers | Astrocytes from lamina cribrosa are involved in the autoregulatory function of optic nerve head vessels in vitro PurposeTo investigate the role of the lamina cribrosa (LC) astrocytes in the autoregulatory capacity of optic nerve head (ONH) vessels and to explore the und...

What if #astrocytes steer optic nerve head blood flow?

Study shows OGD/R → mTOR activation in LC astrocytes, ↑PGE₂, and relaxed VSMCs, supporting astrocyte-driven autoregulation. Hypoxia verified with OxyLite (<10 mmHg after 1 h).
#OxyLite often lets teams fine-tune media pO₂ to in-vivo levels.

Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson’s disease - Nature Neuroscience Parkinson’s disease (PD) involves toxic protein buildup and energy failure in neurons. Continuously breathing low-oxygen air protected mice from PD-like neuronal loss and reversed symptoms, even after...

What if less oxygen could protect the Parkinson’s brain? 🧠
Using Oxford Optronix’s #OxyLite sensor, researchers found α-syn aggregation causes brain hyperoxia—& that hypoxia reversed it, restoring motor function.
#Neurodegeneration #ParkinsonsResearch

Read here: www.nature.com/articles/s41...

Intramuscular adrenaline to improve outcomes following cardiac arrest – An experimental porcine study To investigate early intramuscular adrenaline as an add-on treatment for cardiac arrest in a clinically relevant porcine model. We hypothesized that i…

Can early IM adrenaline save more lives after cardiac arrest?
Early IM adrenaline in cardiac arrest boosted adrenaline levels & heart output but didn’t improve ROSC or brain O₂. Brain oxygen monitoring with #OxyLite showed the gap between systemic gains & brain delivery.
#Resuscitation #Neuro #Brain

Head-to-head comparison of V-A ECMO, Impella and ECPELLA in normal ovine hearts - Scientific Reports Scientific Reports - Head-to-head comparison of V-A ECMO, Impella and ECPELLA in normal ovine hearts

Study in Scientific Reports compares ECMO, Impella, and ECPELLA in healthy sheep hearts.

Real-time #OxyLite pO₂ tracking enabled precise MVO₂ calculations across devices.

🧪 A foundational study for future cardiomyopathy models.

#CardiacSupport #Physiology #HeartResearch #AHA #ECMO

First in vitro and in vivo experiments with ultra high-dose rate oxygen ion radiotherapy Within this study we demonstrated the feasibility of ultra-high dose rate (UHDR) oxygen ion irradiation at three different levels of biological comple…

A novel publication data using #OxyLite in vitro:
- Oxygen consumption drops with increasing LETd (0.35→0.18 mmHg/Gy)
- UHDR always lowers O₂ uptake than SDR
Implication: heavy‑ion FLASH may protect normal cells while effectively hitting tumors
#FLASH #RadiationOncology #Tumor

BPS Publications Background and Purpose Pulmonary hypertension (PH) results from pulmonary vasculopathy, initially leading to a compensatory right ventricular (RV) hypertrophy, and eventually to RV failure. Hypoxia ...

ITPP prevents RV failure in PH by addressing hypoxia.
Using #OxyLite sensors, researchers found RV pO₂ dropped to 15 mmHg in PH rats (vs. 31.5 mmHg controls). ITPP raised pO₂ to 22 mmHg, reducing mortality.
Proof that oxygen delivery can rescue a failing heart.
#Cardiology #PulmonaryHypertension

Brainstem depolarization–induced lethal apnea associated with gain-of-function SCN1AL263V is prevented by sodium channel blockade An infant presenting with life-threatening apneic events was found to carry a homozygous SCN1AL263V missense mutation, which caused familial hemiplegic migraine in heterozygous family members. We show...

@pnas.org study: A SCN1A mutation causes lethal apnea by triggering brainstem depolarization.
Using the #OxyLite , researchers tracked pO2, revealing medullary hypoxia occurs after depolarization—showing apnea drives hypoxia.
Key insights for SIDS and sudden death research.
#Apnea #Neuroscience

Photoacoustic imaging of rat kidney tissue oxygenation using second near-infrared wavelengths Conventionally, spectral photoacoustic imaging (sPAI) to assess tissue oxygenation (sO2) uses optical wavelengths in the first near-infrared (NIR-I) window. This limits the maximum photoacoustic imagi...

NIR-II photoacoustic imaging cuts tissue oxygenation error by 50% over NIR-l.
The study was validated with our gold standard #OxyLite sensors for direct and precise pO₂ monitoring in a phantom model.
#Biomedical #MedTech #PhotoacousticImaging #NIR

🔗 pmc.ncbi.nlm.nih.gov/articles/PMC...

On the regulation of arterial blood pressure by an intracranial baroreceptor mechanism Abstract figure legend This experimental animal (rat) study describes the regulation of systemic arterial blood pressure by an intracranial baroreceptor mechanism sensitive to changes in brain perfus...

Brain’s Blood Pressure Control Mechanism Exposed!
New research in @jphysiol.bsky.social shows intracranial baroreceptors adjust systemic BP to protect #cerebral blood flow.
Using #OxyLite, pO₂ data ruled out hypoxia—responses are mechanosensory.
#Neuroscience #Physiology #ScienceDiscovery