PCMD-1 stabilizes the PCM scaffold and facilitates #centriole separation, say Alina Schreiner, Tamara Mikeladze-Dvali @tdvalilab.bsky.social and colleagues: rupress.org/jcb/article/...

@zaninlab.bsky.social
#Centrosome #PCMstability #Celegans #Development #CellDivision

Schreiner, Mikeladze-Dvali et al. @lifescimunich.bsky.social show that CDK-1 primes PCMD-1 for PLK-1 phosphorylation. Mutations in PLK-1 docking sites impair SPD-5 binding, destabilize the PCM, and delay #centriole separation. rupress.org/jcb/article/...

#Centrosome #PCMstability #Celegans

In @jcb.org, Schreiner, Mikeladze-Dvali et al. show that CDK-1 primes PCMD-1 for PLK-1 phosphorylation. Mutations in PLK-1 docking sites impair SPD-5 binding, destabilize the PCM, and delay #centriole separation. rupress.org/jcb/article/...

#Centrosome #PCMstability #Celegans