The #PLA2R Paradox: Seropositive #Membranous #Nephropathy With Negative Staining

#KIRNephrologyRounds

https://doi.org/10.1016/j.ekir.2025.103750

#nephrotopo
La rémission spontanée dans la #GEM n’est pas rare, même avec une protéinurie élevée

📉 >4 g/j → 45 %
📉 >8 g/j → 34 %
📉 Prot. petit PM élevée → 25-30 %
🧪 Anti-PLA2R ↑ → 17-20 %

📌 D’où l’approche individualisée #KDIGO 2021
#Néphrologie #PLA2R #Proteinurie

#Lectin complement pathway activation in anti #PLA2R membranous nephropathy
#complement as a disease mediator and treatment target in #MN

#Lectin complement pathway activation in anti #PLA2R membranous nephropathy
#complement as a disease mediator and treatment target in #MN

Lipiduria in a PLA2R-MN case, #UrinarySediment #UrineMicroscopy ⁦@LGlomcon⁩ #PLA2R #Nephrotic

Monitoring PLA2R-MN with anti-PLA2R abs. Top: serological/clinical remission (IST: Dutch CYC). Bottom: serological but no clinical remission, re-biopsy: 2ry FSGS. #glomerular #PLA2R @LGlomcon

Solo 1/3 de nefropatia membranosa en Argentina fue PLA2R+. Data sesgada por inmunosupresion. De todos modos interesante considerar diferencia genética en Sudamérica en la interacción PLA2R-HLA #KidneyWk #PLA2R ⁦@LaurenceHBeckJ1⁩