💊FDA Approval Update | #FDA recently approved #Yartemlea (#Narosoplimab-wuug) for #hematopoietic stem cell #transplant (#HSCT)-associated thrombotic microangiopathy
🔸Inhibits #lectin pathway effector enzyme — #MASP2
#HematopoieticStemCell #ThromboticMicroangiopathy
Top: Schematic of GP2 filaments, with labeled residue ranges of ZP domains and four N-glycosylation sites. Middle left: Cryo-EM map of GP2 filaments, color-coded according to the schematic above. The density of one of the flexible branches was indicated by a black arrow. Middle right: Atomic model of GP2 filaments, with five N-glycosylation sites marked by arrows. Bottom: Proposed model of GP2 filaments’ function in the digestive tract. The filament core of UMOD and GP2 is colored in dark blue and green, respectively. The EGF domains and D8C/D10C domains in the branches of both proteins are shown in grey and light blue, respectively. High-mannose N-glycans are colored in red. UPEC cells and their adhesive pilus are colored in pink, while the proteases (such as elastase) are colored in yellow.
#Glycoprotein 2 (GP2) filaments protect against infections by acting as decoys for the bacterial #lectin FimH. The #cryoEM structure of GP2 filaments provides insights into filament assembly and #antibacterial function in the digestive tract @plosbiology.org 🧪 plos.io/3HP2obF
Top: Schematic of GP2 filaments, with labeled residue ranges of ZP domains and four N-glycosylation sites. Middle left: Cryo-EM map of GP2 filaments, color-coded according to the schematic above. The density of one of the flexible branches was indicated by a black arrow. Middle right: Atomic model of GP2 filaments, with five N-glycosylation sites marked by arrows. Bottom: Proposed model of GP2 filaments’ function in the digestive tract. The filament core of UMOD and GP2 is colored in dark blue and green, respectively. The EGF domains and D8C/D10C domains in the branches of both proteins are shown in grey and light blue, respectively. High-mannose N-glycans are colored in red. UPEC cells and their adhesive pilus are colored in pink, while the proteases (such as elastase) are colored in yellow.
#Glycoprotein 2 (GP2) filaments protect against infections by acting as decoys for the bacterial #lectin FimH. The #cryoEM structure of GP2 filaments provides insights into filament assembly and #antibacterial function in the digestive tract @plosbiology.org 🧪 plos.io/3HP2obF
Top: Schematic of GP2 filaments, with labeled residue ranges of ZP domains and four N-glycosylation sites. Middle left: Cryo-EM map of GP2 filaments, color-coded according to the schematic above. The density of one of the flexible branches was indicated by a black arrow. Middle right: Atomic model of GP2 filaments, with five N-glycosylation sites marked by arrows. Bottom: Proposed model of GP2 filaments’ function in the digestive tract. The filament core of UMOD and GP2 is colored in dark blue and green, respectively. The EGF domains and D8C/D10C domains in the branches of both proteins are shown in grey and light blue, respectively. High-mannose N-glycans are colored in red. UPEC cells and their adhesive pilus are colored in pink, while the proteases (such as elastase) are colored in yellow.
#Glycoprotein 2 (GP2) filaments protect against infections by acting as decoys for the bacterial #lectin FimH. The #cryoEM structure of GP2 filaments provides insights into filament assembly and #antibacterial function in the digestive tract @plosbiology.org 🧪 plos.io/3HP2obF
A genetically engineered therapeutic #lectin inhibits #human #influenza A virus #infection and sustains robust virus-specific #CD8 T cell expansion, etidiohnew.blogspot.com/2025/05/a-ge...
The Glyco team collaborated with @viblifesciences.bsky.social IRC to unravel the structure of Nictaba, a stress-inducible lectin from tobacco 🌿, uncovering how it binds GlcNAc-containing carbohydrates!🧬 academic.oup.com/glycob/artic...
#PlantScience #StructuralBiology #Lectin #Glycobiology
#Lectin complement pathway activation in anti #PLA2R membranous nephropathy
#complement as a disease mediator and treatment target in #MN
#Lectin complement pathway activation in anti #PLA2R membranous nephropathy
#complement as a disease mediator and treatment target in #MN
