🦟"The long-term persistence of the ( #Wolbachia) wMel strain 🦠 in #RioDeJaneiro is threatened by poor integrated #vector management ( #IVM) and bacterium fitness cost on #Aedes aegypti" by Márcio Galvão Pavan et al. @oficialfiocruz.bsky.social in #PlosNTDs @plos.org
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"Engaging communities in the control of #arboviral diseases: insights from the African region" by Anankpo Gildas Yahouédo et al @who.int in #PlosNTDs
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🪳"Field evidence of #Trypanosoma cruzi infection, diverse host use and invasion of human dwellings by the #Chagas disease vector in #Florida, #USA" by Norman L Beatty et al. in #PlosNTDs
dx.plos.org/10.1371/jour...

Assessing chikungunya’s economic burden and impact on health-related quality of life: Two systematic literature reviews Author summary Chikungunya is a mosquito-borne illness that has rapidly spread across tropical and subtropical regions, presenting a substantial public health threat. The infection with the chikunguny...

🦟 "Assessing #chikungunya’s economic burden and impact on health-related quality of life: Two systematic literature #reviews" by Giorgia Tiozzo et al. #PlosNTDs
journals.plos.org/plosntds/art...

Pretty blooms in Khon Kaen and even brighter vibes from our latest submission — big thanks to #Reviewer1 for being super clear and #Reviewer2 for thoughtful, constructive feedback that really pushed the work forward. Love the #PLOSNTDs and #parasite communities! 😍

Patient insights research exploring disease awareness, patient life experience, and current management of visceral leishmaniasis in Bihar, India Author summary This is an interview-based investigation of patient awareness, experience, and individual challenges for adults and caregivers of children seeking diagnosis and effective care for visce...

People affected by visceral #leishmaniasis face many obstacles to accessing diagnosis and treatment.
👉 Read about patients’ experiences in this qualitative study in Bihar, India, published in #PLOSNTDs doi.org/10.1371/jour...

New Publication from NGDI UBC Researchers #PLOSNTDs: Development and deployment of a solid oral amphotericin B dosage form to treat visceral leishmaniasis: journals.plos.org/plosntds/art...

Maternal and congenital toxoplasmosis in Mayotte: Prevalence, incidence and management Author summary Toxoplasmosis, a zoonotic disease caused by a ubiquitous protozoan parasite Toxoplasma gondii is usually asymptomatic. However, maternal infection during pregnancy can cause congenital toxoplasmosis with potentially severe neurologic or ophthalmological sequelae. Prevalence varies from country to country depending on socio-economic conditions, dietary habits and hygiene and the prevalence is higher in resource-poor countries. In Mayotte (a French overseas territory), recommendations for toxoplasmosis prevention and screening are partially applied. Indeed, many women don’t speak French, serological follow up is generally irregular and responsible for delayed introduction of treatment and consequently more congenital toxoplasmosis cases. To our knowledge, few published data were available on maternal and congenital toxoplasmosis for this territory. A better understanding of the epidemiology of this parasite would allow surveillance, information and limitation of maternal-fetal transmission to reduce the number of congenital toxoplasmosis cases and improve the management of toxoplasmosis in Mayotte.

#PLOSNTDs: Maternal and congenital toxoplasmosis in Mayotte: Prevalence, incidence and management

dx.plos.org/10.1371/journa…

#PLOSNTDs: Intensive Circulation of Japanese Encephalitis Virus in Peri-urban Sentinel Pigs near Phnom Penh, ... Sentinel flocks?! Nope..... we have #SentinelPigs!

Leptospirosis as a risk factor for chronic kidney disease... Author summary Leptospirosis is an infection that can aff...

#PLOSNTDs: Leptospirosis as a risk factor for chronic kidney disease: A systematic review of observational st ... http://dx.plos.org/10.1371/journal.pntd.0007458

Revisiting the taxonomy and evolution of pathogenicity of... Author summary Leptospirosis which is an emerging zoonoti...

#PLOSNTDs: Revisiting the taxonomy and evolution of pathogenicity of the genus Leptospira through the prism o ... http://dx.plos.org/10.1371/journal.pntd.0007270

Flagellin-independent effects of a Toll-like receptor 5 p... Author summary Toll-like receptors (TLRs) are important r...

#PLOSNTDs: Flagellin-independent effects of a Toll-like receptor 5 polymorphism in the inflammatory response to Burkholderia pseudomallei
http://dx.plos.org/10.1371/journal.pntd.0007354

Modulation of Hemostatic and Inflammatory Responses by Le... Author Summary Leptospirosis is one of the most relevant ...

#PLOSNTDs: Modulation of Hemostatic and Inflammatory Responses by Leptospira Spp.

http://dx.plos.org/10.1371/journal.pntd.0004713

Experimental Zika virus infection of Jamaican fruit bats (Artibeus jamaicensis) and possible entry of virus into brain via activated microglial cells Author summary The rapid spread of Zika virus through a naïve population in the Americas resulted in novel and severe disease manifestations, including fetal and neonatal microcephaly, and GBS. These disease complications make understanding the pathology and ecology of ZIKV a priority. Captive Jamaican fruit bats were challenged with ZIKV to determine their susceptibility, to assess whether bats may play a role in virus ecology, and if they might serve as an animal model to better understand ZIKV pathophysiology. The bats became acutely infected and mounted an antibody response. Three terminally euthanized inoculated bats had antibody titers of 3200, 28 days PI. Evidence of virus replication and associated pathologies were found in the brain, testes, lungs and salivary glands of some of the inoculated bats. The virus showed predilection for mononuclear cells, including resident Iba1+ macrophage/microglial cells, and Leydig cells. With no discernible disruption to the blood brain barrier nor distribution of viral antigen indicative of circumeventricular neuroinvasion, microglia cells may be a possible route of entry of ZIKV into brains of bats. Further investigations are needed to determine the mechanisms of neuroinvasion of ZIKV in bats, further determine feasibility of bats as an alternative animal-model for congenital Zika syndrome, and what role bats might play in ZIKV viral ecology.

#PLOSNTDs: Experimental Zika virus infection of Jamaican fruit bats (Artibeus jamaicensis) and possible entry ...

dx.plos.org/10.1371/journa…

A nonsense mutation in TLR5 is associated with survival a... Author summary Melioidosis is a high-mortality infectious...

#PLOSNTDs: A nonsense mutation in TLR5 is associated with survival and reduced IL-10 and TNF-α levels in human melioidosis http://dx.plos.org/10.1371/journal.pntd.0005587

Type 3 Secretion System Cluster 3 Is a Critical Virulence... Author Summary Respiratory melioidosis is a lethal diseas...

#PLOSNTDs: Type 3 Secretion System Cluster 3 Is a Critical Virulence Determinant for Lung-Specific Melioidosis http://dx.plos.org/10.1371/journal.pntd.0003441

Hemophagocytosis in Experimental Visceral Leishmaniasis b... Author Summary Anemia is one of the major clinical manife...

#PLOSNTDs: Hemophagocytosis in Experimental Visceral Leishmaniasis by Leishmania donovani http://dx.plos.org/10.1371/journal.pntd.0004505

Oral Challenge with Wild-Type Salmonella Typhi Induces Di... Author Summary Typhoid fever continues to be a public hea...

#PLOSNTDs: Oral Challenge with Wild-Type Salmonella Typhi Induces Distinct Changes in B Cell Subsets in Individuals Who Develop Typhoid Disease
http://dx.plos.org/10.1371/journal.pntd.0004766

Expression and Function of S100A8/A9 (Calprotectin) in Hu... Author Summary Bacterial pathogens are recognized by the ...

#PLOSNTDs: Expression and Function of S100A8/A9 (Calprotectin) in Human Typhoid Fever and the Murine Salmonella Model http://dx.plos.org/10.1371/journal.pntd.0003663

Rapidly Escalating Hepcidin and Associated Serum Iron Sta... Author Summary An adequate supply of iron is essential fo...

#PLOSNTDs: Rapidly Escalating Hepcidin and Associated Serum Iron Starvation Are Features of the Acute Response to Typhoid Infection in Humans
http://dx.plos.org/10.1371/journal.pntd.0004029

Neutrophil Extracellular Traps are Involved in the Innate... Author Summary Neutrophils extracellular traps (NETs) are...

#PLOSNTDs: Neutrophil Extracellular Traps are Involved in the Innate Immune Response to Infection with Leptospira http://dx.plos.org/10.1371/journal.pntd.0003927

The gut microbiota as a modulator of innate immunity duri... Author summary Melioidosis is a common cause of community...

#PLOSNTDs: The gut microbiota as a modulator of innate immunity during melioidosis http://dx.plos.org/10.1371/journal.pntd.0005548

Platelet dysfunction contributes to bleeding complication... Author summary Bleeding is a frequent complication of lep...

#PLOSNTDs: Platelet dysfunction contributes to bleeding complications in patients with probable leptospirosis http://dx.plos.org/10.1371/journal.pntd.0005915

High-Throughput Parallel Sequencing to Measure Fitness of... Author Summary Leptospirosis is a neglected infectious di...

#PLOSNTDs: High-Throughput Parallel Sequencing to Measure Fitness of Leptospira interrogans Transposon Insertion Mutants during Acute Infection http://dx.plos.org/10.1371/journal.pntd.0005117

Leptospira interrogans causes quantitative and morphologi... Author summary Pathogenic Leptospira causes the life-thre...

#PLOSNTDs: Leptospira interrogans causes quantitative and morphological disturbances in adherens junctions and other biological groups of proteins in human endothelial cells
http://dx.plos.org/10.1371/journal.pntd.0005830

A 2015 outbreak of flea-borne rickettsiosis in San Gabrie... Author summary Outbreaks of flea-borne rickettsiosis are ...

#PLOSNTDs: A 2015 outbreak of flea-borne rickettsiosis in San Gabriel Valley, Los Angeles County, California

http://dx.plos.org/10.1371/journal.pntd.0006385

The impact of school water, sanitation, and hygiene impro... Author summary Water, sanitation, and hygiene (WASH) in s...

#PLOSNTDs: The impact of school water, sanitation, and hygiene improvements on infectious disease using serum antibody detection

http://dx.plos.org/10.1371/journal.pntd.0006418

Blood coagulation abnormalities in multibacillary leprosy... Author summary Hemostatic illnesses are frequently associ...

#PLOSNTDs: Blood coagulation abnormalities in multibacillary leprosy patients http://dx.plos.org/10.1371/journal.pntd.0006214

Ecological niche modeling and distribution of Ornithodoro... Author summary The model presented here provides valuable...

#PLOSNTDs: Ecological niche modeling and distribution of Ornithodoros hermsi associated with tick-borne relapsing fever in western North America
http://dx.plos.org/10.1371/journal.pntd.0006047

Rapid, actionable diagnosis of urban epidemic leptospiros... Author summary In this study, we describe the performance...

#PLOSNTDs: Rapid, actionable diagnosis of urban epidemic leptospirosis using a pathogenic Leptospira lipL32-based real-time PCR assay
http://dx.plos.org/10.1371/journal.pntd.0005940