Did the FDA just approve a new antipsychotic without a single clinical trial?

Find out what makes Bysanti not-so-different:
psych-partners.com/milsaperidon...

#psychiatry #pmhnp #bipolar #schizophrenia

The secret is out:
▪ A newly approved antipsychotic is identical to one that is about to go generic.

Read this before the next Vanda rep stops by:
psych-partners.com/milsaperidon...

#psychiatry #pmhnp #schizophrenia #bipolar #medicine

Medications don't treat anorexia, but zinc might, and #CBD improved weight in this first placebo controlled trial:
▪ Small, barely positive
▪ Has a theoretical basis

Full details:
psych-partners.com/cbd-for-anor...

#psychiatry #pmhnp #eatingdisorder

New study clarifies risks of antipsychotics in pregnancy (for psychotic disorders):
▪ 60% higher risk of relapse if stopped during pregnancy
▪ Antipsychotics are not teratogenic, but some raise risk of gestational diabetes

More guidance:
psych-partners.com/pregnancy-an...

#pmhnp #obgyn

Probiotics failed in the first randomized trial to test them for substance-induced #depression.

Full details of this small study are here, along with supplements that have a role in substance use disorders:
psych-partners.com/probiotics-f...

#addiction #therapy #pmhnp #psychiatry #naturalhealth

Do diabetes meds protect kidneys on #lithium?

Li-renal function improved on SGLT2 Inhibitors in new cohort study (they are known to protect the kidneys)

Evidence grade: Low (4/10) cohort study

NAC is another possibility; details at:
psych-partners.com/protecting-t...

#psychiatry #pmhnp

Dreaming of a hybrid work-life balance? 🌟 We're seeking a bilingual Psych NP in the Bronx! Flex your skills, enjoy great benefits, and only come in once a week! Ready to join a mission-driven team? Apply now! 🚀 #PMHNP #HybridWork #BronxJobs #MentalHealthCareers

We put Jeffery #Epstein on the couch in the Carlat #Psychiatry Podcast as we explore...

▪ Narcissism
▪ Psychopathy
▪ Machiavellianism
▪ The "Warrior" gene

And a new psychodynamic therapy for antisocial personality:
www.thecarlatreport.com/blogs/2-the-...

#psychology #psychiatry #pmhnp

Low-dose naltrexone has grown in popularity for depression, but the second randomized trial just turned up negative.

Get the full details on this anti-inflammatory set-back:
psych-partners.com/low-dose-nal...

#psychiatry #pmhnp #naturopathic #therapy #naturopathicmedicine

Light therapy improved anhedonia in new small trial of #depression, but only when delivered in morning.

Evidence grade moderate (7/10)

More details and practical tips on timing light therapy:
psych-partners.com/light-therap...

#psychiatry #pmhnp #therapy #naturaltherapy #mentalhealth

Dextromethorphan augmented #clozapine in new randomized trial of #schizophrenia with a large effect.

With few options in clozapine-resistant cases, even a small trial is a worthy addition.

More details:
psych-partners.com/clozapine-de...

#psychiatry #pmhnp

Dextromethorphan Helps When Clozapine Fails in Schizophrenia - PsychPartners Dextromethorphan is the key ingredient in the antidepressant Auvelity, and in this study it improved difficult-to-treat schizophrenia

Dextromethorphan augmented #clozapine in new randomized trial of #schizophrenia with a large effect.

With few options in clozapine-resistant cases, even a small trial is a worthy addition.

More details:
psych-partners.com/clozapine-de...

#psychiatry #pmhnp

ProLivRx is at-home wearable device for #depression, FDA-approved based on one trial:
▪ 124 w/ failure of avg of 1.8 antidepressants
▪ Large effect size over 8 wk, more benefit at 16 wks
▪ Blind intact

Detailed report at practice implications:
psych-partners.com/wearable-hea...

#psychiatry #pmhnp

Who's at risk for sleep med misuse?
▪ Higher income/education
▪ White (non-Hispanic) race
▪ Same-sex attraction
▪ Chronic health conditions
▪ Poor mental health
▪ History of incarceration

From large cross-sectional study:
psych-partners.com/sleep-med-mi...

#psychiatry #pmhnp #medicine #therapy

Jeffrey Epstein on the Couch: Part 1 Narcissism, antisocial, pedophilia… We examine the diagnoses people invoke to explain Jeffrey Epstein and determine if any fit.

Diagnosing #Epstein.

A 4-part fact based podcast from the editor of the Carlat #Psychiatry Report:
www.thecarlatreport.com/blogs/2-the-...

Script below or search for "Carlat" in your podcast app.

#psychology #pmhnp #CriminalPsychology #ForensicPsychology

www.hackedexams.com/item/122979/...
Master Pmhnp I The Ultimate Cmn 552 Study Companion 2025 2026 Edition University Of South Alabama Your Key To Acing Exams
#Pmhnp #UltimateCmn #Cmn552 #StudyCompanion #testbank #testbankexams #testbank2025 #studyguide #hackedexams

New study adds weight to the brain risks of US #football:
pubmed.ncbi.nlm.nih.gov/41758517

▪ Cross-sectional, n=3970
▪ Football linked to worse later-life cognitive and neuropsychiatric function
▪ Worse with longer or professional play

#neurology #psychiatry #psychology #therapy #pmhnp

Which psych disorders worsen during menopause?
▪ Schizophrenia, bipolar, depression, ADHD...

And new analysis adds #OCD, which worsened in 27% but improved in 11%:
pubmed.ncbi.nlm.nih.gov/41249024

#psychiatry #pmhnp #womenshealth #therapy

Spirituality lowers the risk of #alcohol and drug use by 13%, and more for group religious practice (18%). From new analysis:
pubmed.ncbi.nlm.nih.gov/41706493

Learn how Carl Jung inspired the spiritual direction of #AA in the Carlat Podcast:
www.thecarlatreport.com/blogs/2-the-...

#therapy #pmhnp

Difficult to Treat Depression: A Carlat Guide Amazon.com: Difficult to Treat Depression: A Carlat Guide (Audible Audio Edition): Chris Aiken, Chris Aiken, Kellie Newsome, Carlat Publishing: Books

We've unleashed the pramipexole chapter from Difficult to Treat #Depression in new Carlat #Psychiatry Podcast:
www.thecarlatreport.com/blogs/2-the-...

From the audiobook:
amzn.to/47lzsl9

#pmhnp #medicaleducation #bipolar

Benzo use has fallen in the US, particularly in older adults (7.2% to 4.7%), accelerating a trend that began in 2013.
pubmed.ncbi.nlm.nih.gov/41734365

Our latest coverage on how to use and deprescribe them:
www.thecarlatreport.com/articles/536...

#psychiatry #pmhnp #anxiety

Antidepressants increased risk of mania/mixed states 30% in new, large cohort study of #bipolar I disorder over one year:
pubmed.ncbi.nlm.nih.gov/41699856

Evidence grade low (4/10):
chrisaikenmd.com/ebm

What are you seeing with them in practice?

#psychiatry #pmhnp #mentalhealth

Saffron in #depression and #anxiety:
▪ 34 RCTs involving 1769 patients
▪ Significant effect in self-reported scales
▪ Effects on objective scales less clear
pubmed.ncbi.nlm.nih.gov/41693488

Also improves sleep quality, sexual function, weight. How to use:
chrisaikenmd.com/supplements

#pmhnp

How do you deprescribe in psychiatry?

Short answer: Taper gradually

Long answer: Add behavioral strategies for over-medicated symptoms. Learn them for #ADHD and #anxiety in the Feb Carlat Report:
www.thecarlatreport.com/newsletters/...

#psychiatry #pmhnp #therapy #mentalhealth

Which sleep meds have lowest risk of misuse/withdrawal?

Orexin antagonists were safest in new analysis of FDA reports:
www.ncbi.nlm.nih.gov/pubmed/41684...

They also improve next-day cognition and don't cause falls.

Anyone have luck getting approved?

#psychiatry #pmhnp Art: Duane Michals

Steve Hayes developed Acceptance and Commitment #Therapy (ACT) after searching for a way out of his own panic disorder.

We interview Hayes in the Carlat #Psychiatry Podcast:
www.thecarlatreport.com/blogs/2-the-...

#anxiety #pmhnp #therapist #mentalhealth #psychology

DSM-6 hopes to bring attention to:
▪ Spectrum disorders
▪ Quality of life
▪ Environmental, cultural, and biological contributions

And a new name: Diagnostic and SCIENTIFIC Manual

The party begins in the new issue of AJP:
psychiatryonline.org/journal/ajp

#psychiatry #pmhnp #psychology #therapy