#Clozapine saves lives—but #myocarditis is a hidden #risk 🫀 Using patient #heart cells, researchers found #DNA methylation markers that could help predict who’s at risk. Toward safer personalized #psychiatry 🧠 #Schizophrenia #iPSC
https://ow.ly/XSgP50Yh82W
Dextromethorphan augmented #clozapine in new randomized trial of #schizophrenia with a large effect.
With few options in clozapine-resistant cases, even a small trial is a worthy addition.
More details:
psych-partners.com/clozapine-de...
#psychiatry #pmhnp
Dextromethorphan augmented #clozapine in new randomized trial of #schizophrenia with a large effect.
With few options in clozapine-resistant cases, even a small trial is a worthy addition.
More details:
psych-partners.com/clozapine-de...
#psychiatry #pmhnp
Mayoría de los pacientes con un primer episodio psicótico responden a risperidona y amisulpiride, y en los que no responden, clozapina es más eficaz que olanzapina y amisulpiride #clozapine #psychosis jamanetwork.com/journals/jam...
#Clozapine can be life-changing for treatment-resistant #schizophrenia — but rare #heart inflammation limits its use.
New #prize-winning research uncovers epigenetic differences that may explain why some #patients are at risk. 🫀🧬
https://ow.ly/jYX150Ypc94
In a case of treatment-resistant schizophrenia, low-dose #fluvoxamine increased #clozapine levels by >500%, with effects comparable to higher doses, suggesting CYP1A2 inhibition may be dose-independent in some patients.
🔗Read more in JCP: journals.lww.com/psychopharma...
How can specialist services tackle unmet need in severe mental illness?
The Targeted TUNE‑UP clinic shows how.
A new study highlights how this service improves access to #clozapine, enabling safe initiation outside hospital and better outcomes for patients.
tinyurl.com/OHBRCclozapine
Proper use of drug
#Clozapine through the lens of Instagram
#Clozapine #Psychotropic #Drug #Social #Networks
www.em-consulte.com/article/1795...
New JCP data from long-term #clozapine therapeutic drug monitoring show that #smokers have lower plasma clozapine serum levels than nonsmokers, yet adverse reactions can occur at lower concentrations in smokers.
🔗 Read more in our current issue: journals.lww.com/psychopharma...
#Weight loss can affect #clozapine levels in patients with treatment-resistant #schizophrenia 📉 New case shows substantial decrease in drug levels with lifestyle changes and semaglutide use—highlighting the importance of therapeutic drug monitoring. #Clozapine #GLP1 #Ozempic
doi.org/10.1503/jpn....
Clozapine’s agranulocytosis risk peaks in the first 6 months then drops but never disappears
FDA dropped REMS but left old monitoring rules
New guidance:
🩸 Weekly ANCs ×18 wks
📅 Monthly ×2 yrs
✅ Then stop if stable
#Psychiatry #Clozapine #schizophrenia #mentalhealth #medication #psychiatrist
A new study in JCP found that higher BMI was significantly associated with remission in patients on #clozapine, supporting the idea of a “metabolic threshold” for antipsychotic efficacy.
🔗 Read more in our current issue: journals.lww.com/psychopharma...
Clozapine and infection risk: new evidence from Hong Kong’s 20-year cohort study 🧵
This study of 11,000+ patients found clozapine users had a 25% higher risk of infections compared to those on olanzapine, with older adults most vulnerable.
#Schizophrenia #Clozapine #InfectionRisk #ParityOfEsteem
Check the paper to understand how this meta-analysis explored global disparities and charts a path to build competence across the entire healthcare team🌍
doi.org/10.1017/neu....
#Clozapine #Schizophrenia #MentalHealthPolicy #InterprofessionalEducation #Psychiatry #Pharmacy #Nursing
Clozapine remains underutilized despite its efficacy in treatment-resistant #schizophrenia. In a new 12-year review published in our current issue, only 7.5% of #clozapine users discontinued due to serious side effects, most manageable with monitoring.
🔗 journals.lww.com/psychopharma...
Clozapine — is the stringency of its blood monitoring rules causing more harm than good?
#mentalhealth #schizophrenia #clozapine #ukhealthcare
Clozapine is often avoided in treatment-resistant #schizophrenia due to concerns about its metabolic side effects. A new study in JCP challenges that assumption by comparing #metabolic outcomes in patients treated with #clozapine versus other #antipsychotics.
🔗 journals.lww.com/psychopharma...
while 18% to 55% of people with #schizophrenia & schizoaffective disorder experience suicide attempts, clozapine is the only approved & to reduce suicidal behaviour & recently FDA Eliminates the #Clozapine REMS What Comes Next? @jama.com
jamanetwork.com/journals/jam...
#Medsky🧪 #neurosky #publichealth #Clozapine is the only Rx approved by FDA for #Trichotillomania . It is considered the gold standard & a 1st-line #antipsychotic for TRS in treatment guidelines, incl those published by the APA.
A new retrospective study of 14 pregnancies in women with schizophrenia treated with #clozapine found a 36% #miscarriage rate, but no congenital malformations among live births, normal infant growth, and no adverse effects during breastfeeding.
🔗 Read more: journals.lww.com/psychopharma...
*Clozapine: is it time to relax blood monitoring rules?*
New evidence suggests that the stringency of rules around #clozapine may be causing more harm than good. #SophieWillis reports
Clozapine — is the stringency of its blood monitoring rules causing more harm than good?
#mentalhealth #schizophrenia #clozapine #ukhealthcare
In our latest feature, #SophieWillis highlights how new evidence suggests that the stringency of frequent blood monitoring for patients taking clozapine may be causing more harm than good
#ukpharmacy #mentalhealth #clozapine
buff.ly/HJtqX0A
💡 New Findings in Clozapine Pharmacokinetics
🔗 Read the study here: doi.org/10.1038/s415...
#Clozapine #Pharmacokinetics #Inflammation #Schizophrenia
New study of over 120,000 #clozapine therapeutic drug monitoring samples finds #smokers may need lower #plasma levels than nonsmokers for treatment-resistant #schizophrenia. Adverse drug reactions appear earlier in nonsmokers, particularly in women.
🔗 Read more: journals.lww.com/psychopharma...
Thanks @valeriamondelli.bsky.social yes it was a great session and allowed us to discuss important #psychiatry treatments like #clozapine, #ECT, #valproate and #antipsychotics, and to hear also the voice of people with #livedexperience of #mentalhealth difficulties.
Fantastic clinical session with final panel discussion at #BAP2025 on “Myth-busting the (should not be) controversial treatments in psychiatry: A review of clinical evidence” chaired by @carminepariante.bsky.social
#valproate
#antipsychotic
#clozapine
#ECT
#livedexperience
@bapsych.bsky.social
⚠️ART. Riesgo comparativo de mortalidad de los antipsicóticos en 41.695 pacientes con #esquizofrenia: un estudio de cohorte poblacional de 11 años en Hong Kong #schizophrenia #clozapine #antipsicoticos
People with #schizophrenia lived longer on #clozapine than other antipsychotics in this 11-year study of 41,695 from Hong Kong, confirming earlier findings:
www.ncbi.nlm.nih.gov/pubmed/40412...
Long-acting injectables (LAIs) also had an edge, particularly paliperidone.
#psychiatry #pmhnp
🎧 New JCP podcast: Dr. Jose de Leon joins Dr. Julia Ann Koretski to discuss practical strategies for prescribing #clozapine — from titration to genetic variability — and why it’s a life-saving tool in #schizophrenia care.
jcpjournal.libsyn.com/practical-st...
