Cryo-EM led analysis of open and closed conformations of Chagas vaccine candidate TcPOP - Nature Communications Chagas disease, caused by Trypanosoma cruzi, lacks an effective vaccine. Here, the authors report the cryo-EM structure of TcPOP, a potential vaccine antigen, in open and closed states and validate it...

#TuesdayReads:
Struwe Group et al reveal the structure of a key Trypanosoma cruzi enzyme, TcPOP, and show its potential as a Chagas disease vaccine target through invasion-blocking immune responses.
🔗 www.nature.com/articles/s41...
#ChagasDisease #VaccineResearch #CryoEM #ParasiteBiology

#MalariaResearch
#StructuralBiology
#VaccineDevelopment
#Biophysics
#InfectiousDiseases
#ParasiteBiology
#ProteinStructure
#HostPathogenInteractions
#StructuralVaccinology
#GlobalHealth @oxfordbiochemistry.bsky.social @parasitematt.bsky.social @medsci.ox.ac.uk #KavliOxford

#Malaria #Immunology #ParasiteBiology #HostPathogen #StructuralBiology #KavliOxford @parasitematt.bsky.social @medsci.ox.ac.uk @oxfordbiochemistry.bsky.social

Post-doc offer at LPHI - Laboratory of Pathogens and Host Immunity Post-doc in malaria genomics open to individuals from Low and Middle-Income Countries (LMIC) 2025 PostDoc_Montpellier_MalariOmicsDownload

🚨 Postdoc Alert!
1-year position in Plasmodium genomics at Montpellier 🇫🇷
🔬 Focus: P. falciparum Omics from field isolates
🌍 Open only to LMIC applicants
📈 Bioinformatics | Genomics | Transcriptomics
👉 lphi.umontpellier.fr/job-offers/p...
#Malaria #Postdoc #Genomics #ParasiteBiology #LMIC

#MeetTheLab

Introducing the Higgins Lab from @oxfordbiochemistry.bsky.social this week!

Led by #KavliOxford Prof. Matt Higgins, the group studies how parasites invade, acquire nutrients, and evade immunity—guiding better vaccine design.

#ParasiteBiology #VaccineResearch

1/ Toxoplasma gondii manipulates host cells early in infection, arresting the cell cycle and triggering DNA damage. This breakthrough reveals a MYR1-dependent mechanism driving genome instability. Let's dive in!
#ToxoplasmaGondii #ParasiteBiology