Top left: Immunofluorescence of PMP70 staining in young and aged human colons. Young and aged Normal para-carcinoma colons were collected. The boxed areas indicate crypts. Bottom left: TEM from the mouse colon crypt. Green dashed lines: ISC; Pex, peroxisomes; Mito: mitochondrion. Right: Model summarizing the findings of the current study.

How does #aging disrupt intestinal #StemCell (ISC) lineage fidelity and epithelial barrier function? This study shows that low PEX5 impairs #peroxisomal protein import, leading to ISC mis-differentiation; #aspirin rescues this by enhancing β-oxidation of VLCFAs @plosbiology.org 🧪 plos.io/49rBoJf

Top left: Immunofluorescence of PMP70 staining in young and aged human colons. Young and aged Normal para-carcinoma colons were collected. The boxed areas indicate crypts. Bottom left: TEM from the mouse colon crypt. Green dashed lines: ISC; Pex, peroxisomes; Mito: mitochondrion. Right: Model summarizing the findings of the current study.

How does #aging disrupt intestinal #StemCell (ISC) lineage fidelity and epithelial barrier function? This study shows that low PEX5 impairs #peroxisomal protein import, leading to ISC mis-differentiation; #aspirin rescues this by enhancing β-oxidation of VLCFAs @plosbiology.org 🧪 plos.io/49rBoJf

Top left: Immunofluorescence of PMP70 staining in young and aged human colons. Young and aged Normal para-carcinoma colons were collected. The boxed areas indicate crypts. Bottom left: TEM from the mouse colon crypt. Green dashed lines: ISC; Pex, peroxisomes; Mito: mitochondrion. Right: Model summarizing the findings of the current study.

How does #aging disrupt intestinal #StemCell (ISC) lineage fidelity and epithelial barrier function? This study shows that low PEX5 impairs #peroxisomal protein import, leading to ISC mis-differentiation; #aspirin rescues this by enhancing β-oxidation of VLCFAs @plosbiology.org 🧪 plos.io/49rBoJf

New: the largest D-bifunctional protein deficiency cohort in nearly 20 years

Neonatal encephalopathy remains typical, but adult survival is possible even in neonatal-onset cases

And importantly: normal/mild VLCFAs don't rule out DBP-D.
doi.org/10.1002/jimd...
#DBPD #Peroxisomal #RareDisease #JIMD

Happy to share our 🆕review "Role of plant #peroxisomal #catalase in #temperature❄️☀️ and #drought💧🌵 stress: Physio-biochemical and #molecular perspectives" is out in PPB @elsevierconnect.bsky.social 🥳🤩

🔗 sciencedirect.com/science/article/pii/S0981942825012586

#PlantScience @planteditors.bsky.social

We recently published a #neuropathology case report describing how a gain-of-function mutation in #peroxisomal beta-oxidation (Mitchell Syndrome) affects human neuropathology. It seems certain cell types may be uniquely vulnerable, including sensory #neurons, motor neurons, and myelinating cells.