#S1pr3 drives #PulmonaryFibrosis by promoting #macrophage M2 polarization via the PI3K/Akt‑Stat3 pathway, while S1pr3 inhibitors showed protective effects in mouse models, highlighting S1pr3 as a promising therapeutic target.

#OpenAccess: doi.org/10.1016/j.ge...

Blocking S1PR3 reduces bleomycin-induced pulmonary fibrosis by inhibiting macrophage M2 polarization—a major inflammatory driver in tissue scarring.
#PulmonaryFibrosis #Macrophages #S1PR3 #InflammationBiology
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