Figure 1: Infectivity of JN.1 subvariants in 293T-ACE2 and CaLu-3 cells. (A) Mutations that characterize JN.1-derived subvariants FLiRT, KP.2, KP.3, LB.1, KP.2.3, and KP.3.1.1.

Auch diese Studie untersucht neue Varianten des #SARSCoV2-Virus, die 2024 auftraten und weltweit dominant wurden, darunter LB.1, KP.2.3 und KP.3.1.1, die eine spezifische Mutation namens DelS31 im Spike-Protein aufweisen.

#COVID19 #S31del #Coronavirus #VirusEvolution #KP311 #LB1

(D) Lentivirus-based pseudovirus assay. HOS-ACE2/TMPRSS2 cells were infected with pseudoviruses bearing each S protein of KP.3 and KP.3.1.1. The amount of input virus was normalized to the amount of HIV-1 p24 capsid protein. The percentage infectivity of KP.3.1.1 is compared to that of KP.3. The horizontal dash line indicates the mean value of the percentage infectivity of KP.3. Assays were performed in quadruplicate, and a representative result of four independent assays is shown. The presented data is expressed as the average + SD. Each dot indicates the result of an individual replicate. Statistically significant differences versus KP.3 is determined by two-sided Student's t tests and statistically significant difference (P < 0.05) versus KP.3 is indicated with red asterisk.

und KP.2.3, ist wahrscheinlich eine Schlüsselmutation. Unsere Daten unterstreichen die evolutionäre Bedeutung von S:S31del in den JN.1-Stämmen.“

www.thelancet.com/journals/lan...

#VirusEvolution #COVID19 #SARSCoV2 #Coronavirus #ImpfenSchuetzt #KP311 #S31del

Figure S1. Virological features of KP.3.1.1 (A) Frequency of mutations in KP.3.1.1, and other lineages of interest. Only mutations with a frequency >0.5 in at least one but not all the representative lineages are shown.

Virologische Eigenschaften der #SARSCoV2 KP.3.1.1 Variante

KP.3.1.1 (= JN.1.11.1.3.1.1) hat aufgrund der höheren Infektiosität und der erhöhten Immunflucht das Potenzial, die dominante Variante zu sein. „Insbesondere #S31del im Spike, der gemeinsamen Mutation in KP.3.1.1, LB.1 …

#COVID19 #Corona

Die COVID-19-Sommerwelle in Deutschland. Aktuelle Daten und Einschätzungen zur weiteren Entwicklung.

#Sommerwelle #COVID19 #CovidIsNotOver #Corona #LongCovid #MECFS #SARSCoV2 #Pandemie #CleanAir #ImpfenSchuetzt #MaskUp #KP311 #S31del #FLuQE #VirusEvolution #COVIDIsAirborne

Screenshot Post auf X 20.07.2024, 23:36 Uhr. JWeiland @JPWeiland KP.3.1.1 is really packing a punch. The calculated advantages over KP.2* (FLiRT) on Covspectrum appear to be substantial. I haven't worked to confirm with my own regressions yet. I'd expect this one to exacerbate waves across much of the world. Many of us, including @LongDesert Train @yunlong_cao @EricTopol @siamosolocani @RajlabN @BenjMurrell @dfocosi @Mike_Honey_ and others have been expecting this to be the next variant, and it appears it may be even faster than I first thought.

“Es scheint, dass sie sogar noch schneller sein könnte, als ich zunächst dachte.” - JWeiland @jpweiland.bsky.social

#COVID19 #SARSCoV2 #Corona #KP3 #KP311 #VirusEvolution #CovidIsNotOver #LongCovid #CovidIsAirborne #CleanAir #MaskUp #ImpfenSchuetzt #VaccinesSaveLives #S31del