.@SABCSSanAntonio how many people registered for #SABCS20? And how many of those were #advocates? Writing a piece about how awesome SABCS is for advocates and wanted to include some figures.

and it's a wrap for #sabcs20. I truly hope we can gather in person in 2021. Excellent job @SABCSSanAntonio for converting to a virtual format.

#SABCS20 gotta love Vogl, New York moderating this "from the trenches" session 😊 and even better, the inclusion of #advocate Valencia Robinson 🥰 #bcsm

#SABCS20 can we predict who will respond to #immunotherapy? This data from Keynote-086, pembrolizumab in #metastatic #TNBC as monotherapy (by itself) suggest yes. #bcsm

and sorry not to have supplied any answers - the beast had to go out (and one does NOT want a 100+ lb Great Dane having an accident in the house) #sabcs20 #bcsm

and like that tepid sex life, can we spice up the response to immunotherapy, turning a cold tumor hot? #sabcs20 #bcsm

and like with any other of our treatments (and romantic life), hot tumors can become cold. #sabcs20 #bcsm

#SABCS20 what's hot and cold in immunooncology? #bcsm

to all the smart folks at #sabcs20, re #covid19 and the new vaccine(s): will people who are immunocompromised d/t #cancer tx be likely to mount a sufficient immune response that the vaccine(s) would be expected to be effective?

I still have about 100 posters to look at, and who knows how many bookmarked but not watched live sessions. Clearly that's not happening before #sabcs20 ends this afternoon. #advocate friends: would you want me to tweet about these, even if it's not for a week or two? #bcsm

#SABCS20 can we make any conclusions at this time whether tucatinib or netatinib should be used in people with #brainmets? This panel says can't really say since no head-to-head comparison, need to look at side effects profile and what may be more tolerable to each person. #bcsm

BUT ASCENT shows very little improvement of PFS in people with #brainmets treated with sacituzimab vs physician's treatment of choice. #sabcs20 #bcsm

#SABCS20 what about sacituzimab in #brainmets? 2/10 of the original patients with brain mets are still responding, with shrinkage of their brain mets. #bcsm

#SABCS20 NALA ( the #clinicaltrial, not Simba's girlfriend) showed efficacy for neratinib vs lapatinib, even in leptomeningeal disease. #brainmets #bcsm

#SABCS20 now, for more data from HER2CLIMB (we♥️ HER2CLIMB, TY @SeagenGlobal): not only better PFS and OS, but better QOL. That's a home run. #brainmets #bcsm

#SABCS20 #inflammatory #breastcancer (IBC), like TNBC and HER2+, seems to like the brain. Should we be doing routine brain MRIs in people with #metastatic IBC? I say yes. #brainmets # bcsm

#SABCS20 we desperately need models of leptomeningeal disease and work by Fitzpatrick et al have shown genomic differences in LMD, and developed preclinical models derived from LMD tumors in people. Will post poster later! #brainmets #bcsm #leptomeningeal

#SABCS20 is it time to routinely monitor CTCs in people with MBC? #bcsm

#SABCS20 love seeing researchers using data from the @MBC_Project!! @corrie_painter @Nikhilwagle #bcsm

#SABCS20 it's hard to follow spotlight sessions when your 100 lb 1 yr old rescue Great Dane wants to go out. again. 🙄

#SABCS20 including this trial (first author Dr. @ErikaHamilton9) of an oral SERCA #bcsm

#SABCS20 lots being studied, including SERDs and SERCAs #bcsm

#SABCS20 more on mechanisms of resistance in ER+ #breastcancer, reviewed by Dr Ingrid Mayer #bcsm

#SABCS20 there are many routes ER+ breast cancer can follow towards resistance @chandarS_mskcc #bcsm

#SABCS20 wish we could be listening to and engaging with @FDAOncology breast oncology team members like @DanielleKrolMD in person, but glad @abreastcancer is continuing the very popular #advocate - FDA session virtually. @sandisues #bcsm

it's now 5PM on the Best Coast and therefore socially acceptable for me to have an adult beverage after a day of #SABCS20. My brain and my butt (sitting in a hard kitchen chair all day) hurt. At least IRL I've had walked miles and wouldn't be so stiff! #bcsm

#SABCS20 trying to multitask by watching spotlight 3, the #advocate @abreastcancer Hot Topics, and follow the #tlctransform twitter chat. Bottom line - my brain is too old, too menopausal, and too affected by 12 years of cancer (7 #metastatic) to focus on 1 thing, much less 3!

#SABCS20 should we be measuring serum thymidine kinase levels in ER+ MBC before starting ET + a CDK 4/6 inhibitor? Higher levels and lack of suppression after the first cycle of therapy was correlated with shorter PFS and worse outcome. We need efficacy biomarkers! #bcsm

#SABCS20 changes in circulating tumor DNA (ctDNA) can predict response to therapy in plasmaMATCH analysis. Validation needed. I know some folks trying to get funded to study this in the US. #bcsm

is TMB (tumor mutational burden) something else we should be looking at before starting someone with #metastatic #TNBC on immunotherapy? Those with high TMB did better than those with fewer mutations. #SABCS20