Activation of #macrophage κ-OR inhibits hypoxic pulmonary hypertension (HPH) and right heart dysfunction by upregulating #SCD1, which suppresses #InflammatoryResponses and smooth muscle proliferation, providing strong evidence for its therapeutic potential in treating HPH. #medsky

Macrophage κ-opioid receptor inhibits hypoxic pulmonary hypertension progression and right heart dysfunction via an SCD1-dependent anti-inflammatory response

This new study demonstrates that macrophage κ-opioid receptor (κ-OR) inhibits hypoxic pulmonary hypertension (HPH) and #rightheartdysfunction by up-regulating #SCD1, thereby supporting the potential #therapeutic role of κ-OR activation in the treatment of HPH. #medsky

#OpenAccess: buff.ly/X0ORHCk

Macrophage κ-opioid receptor inhibits hypoxic pulmonary hypertension progression and right heart dysfunction via an SCD1-dependent anti-inflammatory response

This new study demonstrates that macrophage κ-opioid receptor (κ-OR) inhibits hypoxic pulmonary hypertension (HPH) and #rightheartdysfunction by up-regulating #SCD1, thereby supporting the potential #therapeutic role of κ-OR activation in the treatment of HPH.

#OpenAccess: buff.ly/wCZ3D4e

Gain of pancreatic beta cell-specific SCD1 improves glucose homeostasis by maintaining functional beta cell mass under metabolic stress - Diabetologia Aims/hypothesis The key pancreatic beta cell transcription factor v-maf musculoaponeurotic fibrosarcoma oncogene homologue A (MafA) is critical for the maintenance of mature beta cell function and phe...

Pancreatic #beta-cell stearoyl-CoA desaturase 1 (SCD1) is determined as an important therapeutic target in diabetes therapy by stabilising MafA, a key transcription factor for beta cell biology. #DiabetesResearch #pancreaticβCells #Hyperglycemia #SCD1 tinyurl.com/9p22n76b