Weekly reads: Gattaca stack, animal sacks, custom iPS cells, ImmunityBio FDA warning, mouse cloning limit - The Niche Professor discusses regenerative news: Gattaca stack, animal sacks, custom iPS cells, ImmunityBio FDA warning, mouse cloning limit

ICYMI: Weekly #stemcell & #regenerative reads: Gattaca stack, animal sacks, custom iPS cells (is it worth $40K+?), ImmunityBio FDA warning, mouse cloning limit finally reached ipscell.com/2026/03/week... #stemcells

The modulation of MSCs with natural products.

🧬 Natural products → better MSC therapies 🧪

↑ homing, survival, differentiation
↑ immune regulation & oxidative balance
Key compounds: phenols, flavonoids, terpenoids

Framework for regenerative medicine

🔗 doi.org/10.1016/S187...

#StemCells #RegenerativeMedicine #TCM #CJNM 🧪

❓A one-time, durable, and even reversible way to prevent thrombosis? In this preprint, led by @lrbzldz.bsky.social, we show that epigenome editing of 🩸 #StemCells can durably reprogram platelet function: www.biorxiv.org/content/10.6...

📄 New review in JND

Satellite cells are central to muscle regeneration and a growing class of disorders termed satellite cell-opathies.

Emerging therapies include gene editing, cell therapy, and niche-targeting drugs.
Read the full review here: buff.ly/n5brzO7

#StemCells #RareDisease

Japan grants conditional approval to Amchepry for Parkinson’s Japan granted conditional approval to Amchepry, a stem cell-derived therapy for Parkinson’s disease, based on early clinical trial results

🧠 Japanese 🇯🇵 pharma company #Sumitomo has received approval to mass-manufacture a pioneering #StemCells treatment that regenerates dopamine-producing brain cells. Early trials showed over half of #Parkinsons participants showing signs of recovery with no adverse effects. 🌟

Weekly reads: Gattaca stack, animal sacks, custom iPS cells, ImmunityBio FDA warning, mouse cloning limit - The Niche Professor discusses regenerative news: Gattaca stack, animal sacks, custom iPS cells, ImmunityBio FDA warning, mouse cloning limit

Weekly #regenerative reads: Gattaca stack, animal sacks, custom iPS cells, ImmunityBio FDA warning, mouse cloning limit ipscell.com/2026/03/week... #stemcells #stemcell

We’ve been told to eat 3 meals a day.. starting with breakfast as soon as we rise, but why? 🧐 I skip breakfast, and intermittent fast (only eat 12pm-8pm). Fasting gives your body time to heal.. especially while you sleep.

🍽️

#Kellogs #Breakfast #Fasting #Healing #StemCells

Paralyzed Man Regains Use of Arms and Hands After Experimental Stem Cell Therapy - Neuroscience News Researchers inject an experimental stem cell treatment into the damaged cervical spine of a recently paralyzed young man, restoring a level of function into his hands and arms.

Paralyzed after a car crash, regains use of arms with stem cells therapy
#stemcells
neurosciencenews.com/stem-cell-pa...

Engineered MSCs enable bone marrow-targeted immunomodulation Zhang and colleagues developed a bone marrow-targeted, tumor-evasive cell vector that enhances systemic immunity without stimulating tumor growth. By delivering protective or immune-restorative signals directly to immune organs rather than to the tumor itself, their strategy reframes cancer therapy as systemic immune reprogramming instead of localized tumor attack.

Online Now! Engineered MSCs enable bone marrow-targeted immunomodulation #stemcells

Preservation of chondrocyte microspheroids by local sustained hydrogen supply improves osteoarthritic cartilage repair He et al. discover that persistent H2 supply can preserve the viability and phenotype of transplanted chondrocytes in an unfavorable pathological microenvironment of osteoarthritis, and they construct a H2-releasing, chondrocyte-encapsulating hydrogel transplant, thereby realizing the rapid and efficient repair of sheep osteoarthritic cartilage defects and the reversal of osteoarthritic progression within 6 months.

Online Now! Preservation of chondrocyte microspheroids by local sustained hydrogen supply improves osteoarthritic cartilage repair #stemcells

SPTEdU-seq enables parallel optics-free newborn cell tracking and spatial total transcriptional dynamics in intact microenvironments Niu et al. present SPTEdU-seq, a spatial omics platform that enables co-profiling of newborn cell dynamics and full-length total transcriptomes at cellular resolution. This approach illuminates non-coding RNA regulations, spatial splicing, transient states, lineage trajectories, and cellular interactions in the contexts of regeneration, development, and tumor biology.

Online Now! SPTEdU-seq enables parallel optics-free newborn cell tracking and spatial total transcriptional dynamics in intact microenvironments #stemcells

⏳ Time is running out!

The deadline to apply for the #ASCBcourse at @InstitutPasteur is April 5th — don't miss your chance! 🚨

📍 Paris | 📆 June 22 - July 3, 2026
🔬 2 weeks | 9 modules | World-class faculty

Apply now 👉 shorturl.at/PyUHi

#StemCells #PhD #Postdoc

New Stem Cell Therapy Rebuilds Bone in Osteoporosis, Shows 30% Density Gain In the relentless march of ageing, osteoporosis has long been a one-way street: bones thin out, fracture risk soars, and patients are sentenced to lifelong drugs that merely slow the decline. But 2025 may be remembered as the year that changed. In a clinical trial involving 180 postmenopausal women, researchers injected “primed” stem cells directly into sites of low bone density.

Stem cells primed in the lab boosted bone density by 30% in women with osteoporosis, pointing to true regeneration, not just slowing loss.
#Osteoporosis #StemCells #RegenerativeMedicine

Did some of the most famous wellness influencers in the world almost die while under the care of the stem cell doctor to the stars?

#Wellness #Charlatans #JordanPeterson #sepsis #StemCells

youtube.com/watch?v=bpF8...

Pluripotent stem-cell-based screening uncovers sildenafil as a mitochondrial disease therapy Mitochondrial disease encompasses inherited disorders affecting mitochondrial function. A severe and untreatable form of mitochondrial disease is Leig…

Great to see our work published in CELL

Using patient-derived iPSCs and organoids, we identified PDE5 inhibitors as candidates for Leigh syndrome

Early patient data support clinical translation.

Congrats to the team, especially Alessandro Prigione

🔗 tinyurl.com/2sbfk463

#StemCells #Mitochondria

🧩Unique to Qkine - animal origin-free TGF-β1. View TGF-β1 PLUS™ and buy online > zurl.co/Dxa9C

#stemcells #organoids #nams

Can ‘mini brains’ replace lab animals? Organoids are changing how scientists study disease | The-14 Lab-grown organoids offer a humane alternative to animal testing, helping scientists study diseases more accurately and advance personalized medicine research.

Can ‘mini brains’ replace lab animals? Organoids are changing how scientists study disease
#Science #Organoids #MiniBrains #Biomedical #Research #MedicalInnovation #StemCells #Alzheimers #Autism #Brain #LabGrown #HumanCells #Biotech #Toxicology #Ethics
the-14.com/can-mini-bra...

Lucie Germain - 2026 Killam Prize - Killam Laureates Lucie Germain is recognized as a world leader in tissue engineering and regenerative medicine and for translating her discoveries to the clinic. Her fundamental research focuses on developing therapie...

(1/2) Congratulations to Dr. Lucie Germain on being awarded the 2026 Killam Prize in Health from the National Research Council of Canada! 🎉

A Professor at Université Laval and a leader in #RegenerativeMedicine, Dr. Germain is known for her research in #TissueEngineering and #StemCells.

Human pluripotent stem cell-derived atrioventricular node-like pacemaker cells exhibit biological conduction bridge properties Protze and colleagues report a new protocol for the generation of human pluripotent stem cell-derived atrioventricular node-like pacemaker cells (AVNLPCs) via BMP signaling. These AVNLPCs display key AVN conduction properties upon engraftment into guinea pig hearts, representing a promising advancement toward a biological conduction bridge for the treatment of heart block.

Online Now! Human pluripotent stem cell-derived atrioventricular node-like pacemaker cells exhibit biological conduction bridge properties #stemcells

Metabolite-induced DNA damage drives stochastic stem cell loss and clonal hematopoiesis Protection against endogenous formaldehyde is important for blood stem cells throughout life. By studying blood-specific knockout mice and Fanconi anemia patients, Kamimae-Lanning and colleagues reveal that clonal hematopoiesis can arise not just through selective drivers but also through stochastic stem cell attrition, uncovering an alternative pathway shaping blood aging and disease.

Online Now! Metabolite-induced DNA damage drives stochastic stem cell loss and clonal hematopoiesis #stemcells

Decoding the spatiotemporal development of the blood-brain barrier in human cortex Our study systematically reveals the initiation and establishment of the human blood-brain barrier (BBB) using spatiotemporal transcriptomics. By comparing human and mouse BBB development, we demonstrate the evolutionary conservation of this process and identify H2A.Z.1 as a key protein for BBB development.

Online Now! Decoding the spatiotemporal development of the blood-brain barrier in human cortex #stemcells

Come on Steve!
Please support Steve Wylie, long time friend of PET and star volunteer, who is running the Edinburgh marathon to raise funds for PET.
www.justgiving.com/page/stephen...

#fertility #infertility #FertilityTreatment #FertilityClinic #genetics #genomics #stemcells

Lab-grown oesophagus restores pigs’ ability to swallow Engineered tissue could eventually be used for children born with gaps in their alimentary canal, or for adults whose muscles have been damaged by cancer.

In this new study, researchers @paolodecoppi.bsky.social used #stemcells to create bioengineered #oesophagi that they implanted into pigs, restoring their ability to swallow & eat. Their work opens the door for similar structures to treat people with #cancer.
www.nature.com/articles/d41...

Excited to share our review where we provide an updated view of stem & progenitor cells in the mammary gland from development through aging - led by my brilliant graduate student Andrew Olander
link.springer.com/article/10.1...
@stemcellsciencenews.com #stemcells #breastcancer #mammarygland

Weekly reads: the thymus and aging, Aspen upbeat 1 year data, paired organoids - The Niche Stem cell biologist discusses recent research including on Aspen encouraging data at 1 year, thymus and aging, paired organoids.

Weekly reads: intriguing links between the thymus and aging, Aspen upbeat 1 year data on #stemcells for Parkinson's, paired organoids, more ipscell.com/2026/03/week... #stemcell

What is in vivo reprogramming, its potential pros & cons? - The Niche Stem cell biologist discusses in vivo reprogramming, its pros and cons, and the potential applications in regenerative medicine.

What is in vivo reprogramming, its potential pros & cons? ipscell.com/2025/10/what... Why do people & biotechs want very much to only do partial in vivo reprogramming in humans? #stemcells #stemcell

A huge thanks to all our colleagues for their feedback and support throughout this journey! 🥂✨

#DevelopmentalBiology #Neuroscience #SpinalCord #StemCells #ScienceAdvances

🧬 Stem cells → neural cells (neurons, astrocytes, oligodendrocytes)
🔬 Shows in vivo to in vitro neural differentiation
🧪 Driven by key growth factors & gene regulation

📅 Epigenetics Congress 2026 | Oct 15–16
📍 Boston (Hybrid)
🔗 epigeneticscongress.com

#Epigenetics #StemCells

Species-specific chromatin architecture and neurogenesis mediated by a human enhancer How human-specific DNA changes shape brain development is poorly understood. Mosti et al. discover a human enhancer, HAR1984, which drives ETV5 and TRA2B expression via human-enriched chromatin interactions. ETV5-HAR1984 binding generates a positive regulatory feedback, promoting cortical neurogenesis across human and chimpanzee organoids and cortical size and folds in mice.

Online Now! Species-specific chromatin architecture and neurogenesis mediated by a human enhancer #stemcells

Auditory activity sustains adult neurogenesis and cognition through the locus coeruleus-norepinephrine system Liu et al. show that specific ablation of outer hair cells (OHCs) in mice results in cognitive impairment and defective adult hippocampal neurogenesis because of the attenuation of PnCvGluT2 to LCNEergic neuronal afferents. Notably, they demonstrate that stimulating these neuronal afferents can rescue cognitive decline caused by hearing loss.

Online Now! Auditory activity sustains adult neurogenesis and cognition through the locus coeruleus-norepinephrine system #stemcells