🔬 Every diagnosis starts with a question.
In surgical pathology, we study tissues under the microscope to find answers—cancer or not? Infection or inflammation?
It's the hidden science behind every surgery, quietly saving lives one slide at a time.
#SurgicalPathology #BehindTheScenesMedicine

This was the biggest multinucleated giant cell of the week. SCC metastatic to bone. #SkyPath #PathSky #BSTPath #surgicalpathology

Acquired Reactive Perforating Dermatosis is a Variant of Prurigo Nodularis - PubMed Patients with chronic pruritus may develop scratch-induced lesions with elevated borders and central necrosis. This so-called umbilicated type of prurigo (UP) is rare and is assumed to develop prefere...

#blueskypath #pathsky #blueskydermpath #dermpathsky #dermatopathology #surgicalpathology #dermpath #derm #dermatology #pathology #inflammatoryderm

pubmed.ncbi.nlm.nih.gov/27349279/

#pathology #dermatopathology #dermpath #histopathology #surgicalpathology #pathologist #anatomicpathology #pathologyatCooper #pathologyatCUHC

Monotonous oval to spindle cells with minimal cytologic atypia, often demonstrating whorling around blood vessels

LVI

H&E, CD10, ER, PR

Low-Grade Endometrial Stromal Sarcoma (LG-ESS), uterus: Proliferative-phase endometrial stromal-type tumor cells with “tongue/finger-like pattern” of myometrial invasion, frequent LVI - CD10, IFITM1 & ER/PR positive!
#pathology #pathsky #gynpath #oncsky #sarcoma #lgess #surgicalpathology #pathart

Score 0, 1+, 2+, 3 by IHC of a breast carcinoma

The human epidermal growth factor receptor 2 (HER2), one of the most common biomarkers assessed by scoring of IHC-stained tissue: Overexpressed in 15-25% of breast carcinomas (likely to respond to HER2 targeted therapy) #biomarkers #oncology #Her2 #breastcancer #pathology #surgicalpathology #pathsky

Glomus Tumor, index finger, H&Es, 10x, 40x & 100x and immunostains - Composed of 3 components:
1. Glomus cells
2. Vasculature
3. Smooth muscle cells
Vimentin, SMA, h-caldesmon & CD34 positive and CKs & S100 negative!
#pathology #pathsky #softtissuepathology #glomustumor #surgicalpathology #pathart

Androgen receptor immunohistochemical stain

Salivary Duct Carcinoma (SDC), parotid, H&Es,20 & 40x, AR and PAP smears: Aggressive salivary gland adenocarcinoma, abundant eosinophilic (oncocytic) cytoplasm and AR, GATA3 & GCDFP15 positive!
#pathology #pathsky #surgicalpathology #headandneckpathology #cytosky #salivaryductcarcinoma #sdc #pathart

Serous cystadenoma, pancreas, H&Es, 20x, 40x, 100x & DQ/PAP smears: Intracystic/intraluminal papillary projections lined by bland flattened to cuboidal epithelium - EMA, MUC1, inhibin, GLUT1 positive!
#pathology #pathsky #surgicalpathology #cytosky #pancreaticpathology #serouscystadenoma #pathart

Ameloblastoma (follicular type), mandible, H&Es, 20x and 40x: Epithelial nests with a peripheral layer of columnar cells showing "palisading" and "reverse polarity", surrounding a central area resembling the “stellate reticulum” of a developing tooth! #pathology #pathsky #surgicalpathology #pathart

Hybrid tumor: Oncocytoma and Chromophobe Renal cell Carcinoma! #GUpathsky #pathsky #pathology #surgicalpathology #pathart #Nephsky

CD68 immunohistochemical stain

S100 immunohistochemical stain

Granular cell tumor (GCT), tongue, H&Es, 10x and 40x & CD68 and S100, 20x: Large round to oval tumor cells with indistinct eosinophilic, granular cytoplasm - CD68, S100, and SOX10 positive!
#pathology #pathsky #surgicalpathology #granularcelltumor #gct #headandneckpathology #pathart

Cytokeratin 7 immunohistochemical stain

Chromophobe renal cell carcinoma (ChRCC), kidney, H&Es, 20x and 40x, CK7, 20x: Plant-like tumor cells - Vimentin negative; CK7 and C-Kit positive!
#pathology #pathsky #surgicalpathology #renalpathology #renalcellcarcinoma #renalpathology #RCC #kidneypathology #ChRCC #pathart

Invasive Micropapillary Carcinoma (IMPC), breast, H&E, 10x and 40x: Mimics lymphovascular space invasion due to “empty/clear spaces” around the tumor cells!
#pathology #pathsky #surgicalpathology #breastpathology #invasivemicropapillarycarcinoma #IMPC #pathart

Microglandular adenosis (MGA), breast, H&E, 10x and 40x: A rare breast lesion! #pathology #pathsky #surgicalpathology #breastpathology #microglandularadenosis #MGA

#pathology #pathsky #surgicalpathology #breastpathology #lobularneoplasia #ALH

#pathology #pathsky #surgicalpathology #pathart #colonicadenocarcinoma

Challenging Cases in Gynecologic Surgical Pathology 2024 PDF #GynecologicPathology #SurgicalPathology
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Differential Diagnoses in Surgical Pathology Genitourinary System 2nd Edition PDF #SurgicalPathology
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Challenging Cases in Gynecologic Surgical Pathology 2024 PDF #GynecologicPathology #SurgicalPathology
medicalebooks.org/challenging-...

Differential Diagnoses in Surgical Pathology Genitourinary System 2nd Edition PDF #SurgicalPathology
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Diagnostic Pathology: Soft Tissue Tumors, 4th Edition PDF #diagnosticpathology #SurgicalPathology
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Diagnostic Pathology: Soft Tissue Tumors, 4th Edition PDF #diagnosticpathology #SurgicalPathology
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Differential Diagnoses in Surgical Pathology: Breast
Authors: Simpson, Jean F.; Sanders, Melinda E.
Publication: Wolters Kluwer Health
Year: 2016-10-18
ISBN: 9781496300652, 9781496375391
Format: EPUB + Converted PDF
Language: English #SurgicalPathology
medicalebooks.org/shop/differe...

Differential Diagnoses in Surgical Pathology: Breast
Authors: Simpson, Jean F.; Sanders, Melinda E.
Publication: Wolters Kluwer Health
Year: 2016-10-18
ISBN: 9781496300652, 9781496375391
Format: EPUB + Converted PDF
Language: English #SurgicalPathology
medicalebooks.org/shop/differe...

Differential Diagnoses in Surgical Pathology: Breast
Authors: Simpson, Jean F.; Sanders, Melinda E.
Publication: Wolters Kluwer Health
Year: 2016-10-18
ISBN: 9781496300652, 9781496375391
Format: EPUB + Converted PDF
Language: English #SurgicalPathology
medicalebooks.org/shop/differe...