Slow AMPA receptors in hippocampal principal cells - PubMed Glutamate receptor ion channels, including α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, mediate fast excitatory neurotransmission in the CNS. Previous work suggested that AMPA receptors produce a synaptic current with a millisecond duration. However, we find that about two- …

Seth Grant mentions that many synapses do not have NMDA receptors- a key fact that many ignore.

Shameless self promotion: some synapses (in many brain regions) do have terrifically powerful slow AMPA receptors.

See our 2021 paper:

pubmed.ncbi.nlm.nih.gov/34348150/

#iglurs #SynapticDiversity

📄 What a read! In a new PLOS Biology publication, our fluorescent #nanobodies for PSD95, VGluT1 & Syt1 enabled precise, reliable imaging of #synapses in mouse brain — outshining conventional antibodies. 🧠🔬 Full study here: bit.ly/44hYHnM
📸 Fig.1 A&B
#FluoTags #Neuroscience #SynapticDiversity #STED