Even though DMS3 is a #Pseudomonas #phage, Nathan showed that Aqs1 could inhibit the function of other #T4P family ATPases, including #T2SS GspE, PilB from #Stenotrophomonas (twitching) and PilB from #Acinetobacter (DNA uptake). These data point to a new allosteric vulnerability of PilB homologues.

The type II secretion system utilizes GspN for transport of lipoproteins to the Acinetobacter baumannii cell surface | mBio The type II secretion system (T2SS) is considered a virulence factor of Gram-negative pathogens, such as Acinetobacter baumannii. Despite a described function for the majority of the core components of the T2SS, the role of GspN has been unclear, and it was previously reported that GspN is dispensable for protein secretion by this system. Here, we characterize the selective transport of a subset of proteins by the T2SS and show that GspN is required for their outer membrane translocation and surface localization.

Another milestone in the #T2SS research from the
SandkvistLab ‪@sandkvistlab.bsky.social‬ is out in mBio 👍
journals.asm.org/doi/10.1128/...

Identification of factors limiting the efficiency of transplanting extracellular electron transfer chains in Escherichia coli | Applied and Environmental Microbiology Research on transplanting extracellular electron transfer (EET) chains into non-native exoelectrogens is vital for advancing bioenergy and bioremediation technologies. Enabling these organisms to transfer electrons to external surfaces like anodes can ...

It has been long that I have not worked on the type II secretion system #T2SS. Yet amazed about the broad physiological relevance of the system. Here bringing the small cytochrome MtrC to the bacterial cell surface to support extracellular electron transfer (EET). Check at rb.gy/389ugk

Journées Sécrétion 2025 Contact: secretion@imm.cnrs.fr

The second edition of the 'Secretion Days' in Marseille will take place on October 2 and 3, 2025. Please spread the word!
Registration works via a Google form: forms.gle/CCyC4UXEBC55...
#Secretion | #T1SS #T2SS #T3SS #T4SS #T5SS #T6SS #T7SS