This study uncovers a #lncRNA-derived #microprotein, TPM3P9, that drives #ClearCellRenalCellCarcinoma by binding RBM4 to alter #TCF7L2 splicing and activate NF-κB signaling, highlighting TPM3P9 as a therapeutic target in renal cancer. #medsky

#STTT: doi.org/10.1038/s413...

The Longitudinal Effect of Diabetes-Associated Variation in TCF7L2 on Islet Function in Humans The T allele at rs7903146 in TCF7L2 increases the rate of conversion from prediabetes to type 2 diabetes. This has been associated with impaired β-cell fun

Exciting work from Adrian Vella's team at the Mayo Clinic implicating a role for the #TCF7L2 locus conferring its diabetes effect via pancreatic alpha cells

diabetesjournals.org/diabetes/art...